Стан глутатіонової ланки антиоксидантної системи у крові щурів за умов оксидаційного стресу та за дії ліпосомального препарату «бутаселмевіт»

Т. В. Мартишук, О. І. ВІЩУР, Б. В. Гутий

Анотація


STATE OF GLUTATHIONIC LINK OF ANTIOXIDANT SYSTEM IN BLOOD OF RATS UNDER CONDITIONS OF OXIDATIVE STRESS AND FOR THE ACTION OF LIPOSOMAL DRUG «BUTASELMEVIT»

 

T. Martyshuk, O. Vishchur, B. Gutyj

Abstract. The article contains the results of search of the influence of the developed complex liposomal drug «Butaselmevit» on the activity of glutathione system of antioxidant protection in the blood of rats under condition of simulated oxidative stress, caused by the use of carbon tetrachloride.

It is proved that intramuscular injection to rats of experimental group 50% of oil solution tetrachloromethane at a dose of 0.25 ml per 100 g of body weight of animal, causes antigenic load on the body and leads to inhibition of the activity of glutathione system of antioxidant protection of the rats body. This indicates the low activity of glutathione peroxidase and the low level of restored glutathione in the blood of rats.

To enhance the system activity of antioxidant protection for the development of oxidative stress it is advisable to use the liposomal drug «Butaselmevit», which in its structure contains butafosfan, selenium, methionine, milk thistle and vitamins.

It was set up that parenteral injection to rats for the development of oxidative stress of liposomal drug «Butaselmevit» leads to increase activity of glutathione peroxidase and restored glutathione levels in the blood of rats from the experimental group.

The indicated research results show the antioxidant properties of the new liposomal drug «Butaselmevit.»

Keywords: oxidative stress, rats, carbon tetrachloride, glutathione peroxidase, restored glutathione, liposomal drug «Butaselmevit»


Повний текст:

PDF

Посилання


Abragamovich, O. O., Grabovska, O.I ., Terletska, O. I. (2000). Protsesi lipidnoyi peroksidatsiyi pri hronichnih urazhennyah pechinki. Medichna himiya. 2 (1), 5-8. (in Ukrainian).

Antonyak, G. L., Babich, N. O., Sologub, L. I. (2000). Utvorennya aktivnih form kisnyu ta sistema antioksidantnogo zahistu v organizmi tvarin. Biologiya tvarin. 2 (2), 34-43. (in Ukrainian).

Baraboy, V. A., Brehman, I. I., Golovitin, V. G. (1992). Perekisnoe okislenie lipidov i stress. SPb.: Nauka, 268.

Belenichev, I. F. Levitskiy, E. L., Kovalenko, S. I. (2002) Antioksidantna sistema zahistu organizmu (oglyad). Sovremennye problemy toksikologii. 3, 29-31. (in Russian)

Vlizlo, V. V. (2012) Laboratorni metody’ doslidzhen’ u biologiyi, tvary`nny`cztvi ta vetery`narnij medy’cy’ni : dovidny’k / V. V. Vlizlo, R. S. Fedoruk, I. B. Raty`ch ta in.; za red. V. V. Vlizla. L’viv : Spolom, 764 (in Ukrainian).

Gutiy, B. V. (2012). Vpliv hloridu kadmiyu na intensivnist protsesiv perekisnogo okisnennya lipidiv ta stan sistemi antioksidantnogo zahistu organizmu shchuriv. Visnik Sumskogo natsionalnogo agrarnogo universitetu. 7(31), 31-34;

Skry`pny`k, I. M. (2007) Gepatoprotetorni zasoby` v suchasnij gepatologiyi//Consilium Medicumllkraina. 1(5), 11-15. (in Ukrainian).

Shapoval, G. S., Gromovaya, V. F., 2003. Mehanizmy antioksidantnoy zashchity organizma pri deystvii aktivnyh form kisloroda [The mechanisms of antioxidant defense in the action of reactive oxygen species] Ukr. biohim. zhurn. – T. 75, №2. – S. 5-13. (In Russian).

Lee, J. Y., Lee, J. H., Kim, H. J. (2004). The preventive inhibition of chondroitin sulfate against the CCI4-induced oxidative stress of subcellular level. Arch.Pharm.Res. 27 (3), 340-345.

Saba, A. B., Oyagbemi, A. A., Azeez, O. I. (2010). Amelioration of carbon tetrachloride-induced hepatotoxicity and haemotoxicity by aqueous leaf extract of Cnidoscolus aconitifolius in rats. Nig. J. Physiol. Sci. 25, 139-147


Метрики статей

Завантаження метрик ...

Metrics powered by PLOS ALM

Посилання

  • Поки немає зовнішніх посилань.