Показники клітинних та гуморальних факторів неспецифічної резистентності організму коней за різного перебігу увеїту

Анотація

INDICES OF CELL AND HUMORAL FACTORS OF NON-SPECIFIC RESISTANCE OF THE HORSE ORGANISM IN DIFFERENT COURSE OF UVEITIS

1. A. A. Mezhenskyi

Abstract. Because of the considerable distribution of uveites among horses, the study of their pathogenesis, the development of methods of pathogenetically substantiated treatment are the great practical importance and an actual problem of the present.The aim of the work is to study the indices of cellular and humoral factors of the non-specific resistance of the clinically healthy horses organism and horses with acute, subacute and chronic uveitis. In 10 animals from each group, bactericidal (BSA) and lysozyme (LSA) serum activity, phagocytic activity of neutrophils (PA), phagocytic index (PI), and phagocytosis completion index (PCI)) were determined by conventional methods.It was found that in clinically healthy horses all the studied parameters were within the reference values. In horses with acute uveitis, an imbalance of cellular and humoral factors of non-specific resistance of the organism develops, which is manifested by a significant decrease in BSA and LSA, along with an increase in PA and PI, while the phagocytic reaction is complete. In horses with subacute and chronic uveitis, the degree of imbalance of humoral and cellular factors of the non-specific resistance of the horse organism is increased, which is manifested by significant inhibition of BSA, LSA, PA, and also by a decrease in PI, which leads to incompleteness of the phagocytic reaction.Prospects for further development are to study the influence of various methods and means of treating horses with uveitis on the dynamics of the indices of cellular and humoral factors of non-specific resistance of the organism.

Keywords: horse, eye diseases, uveitis, immunity, indices of cellular and humoral factors of non-specific resistance of the organism