DYNAMICS OF SOME BIOCHEMICAL INDICATORS IN CANINE PRBC DURING STORAGE PERIOD



Nikolai Tsvilikhovski, Ivan Yakymchuk, Andriy Makaryn

Анотація


According to the standards of humane medicine, a large
concentration of extracellular potassium may accumulate in the human packed red
blood cells (pRBCs) during storage. Therefore, during transfusion to the recipient
of such pRBCs, there is a risk of developing hyperkalaemia. This is one of the
reasons for a significant restriction of the use of erythrocytic mass in humane
medicine, sometimes after two weeks of storage. In veterinary medicine there is no
research on the dynamics of accumulation of potassium and lactate in the canine
pRBCs. The aim of the study was to determine the concentrations of potassium
and lactate in the canine pRBC for different periods of its storage. According to the
results of the research, the concentration of potassium during the 35-day storage
period of the canine pRBCs significantly increased in 2.1 times from 3.89 ± 0.16
mmol/L to 8.12 ± 0.26 mmol/L, and lactate concentration increased in 10.7 times
from 1.8 ± 0.07 mmol/L to 19.3 ± 0.25 mmol/L, followed by a rapid decrease in
these parameters after the 21st day of pRBC storage. It was established that the
concentrations of potassium and lactate in the canine pRBC on the 35th day of
storage is safe for its transfusion to animals. Moreover, the level of lactate in the
canine pRBC can be used as a criterion for its suitability for transfusion to patients.
In the future, it is important to determine the dynamics of changes in the
morphological parameters of the erythrocytic mass of dogs for different periods of
its storage.
Keywords: dogs, packed red blood cells, potassium, lactate,
glycolysism phosphofructokinase


Повний текст:

PDF

Посилання


Yagi, K., Holowaychuk, M. (2016). Manual of veterinary transfusion

medicine and blood banking. 387.

DiBartolla, S. (2006). Fluid, electrolyte and acid-base disorders in small

animal practice [3 rd edn.]. Elsevier Inc. 331.

Silverstein, D., Hopper, K. (2014). Small animal critical care medicine. [2 nd

edn.]. Elsevier. 274.

Harvey, JW. (2010). Erythrocyte biochemistry, In: Weis, DJ, Wardrop, KJ,

eds. Schalm’s Veterinary Hematology. [6 th edn.]. Hoboken, NJ: Wiley-Blackwell. 131–

Beutler, E. (1996). Red cell metabolism, In: Rossi EC, Simon TL, Moss

GS, et al., eds. Principles of Transfusion Medicine. [2 nd edn.]. Baltimore, MD:

Williams & Wilkins. 37–42.

Beutler, E. (1996). Liquid preservation of red cells, In: Rossi E, Simon T,

Moss G, et al., eds. Principles of Transfusion Medicine. [2 nd edn.]. Baltimore, MD:

Williams & Wilkins. 51–60.

Bernstein, RE. (1954). Potassium and sodium balance in mammalian red

cells. Science. 120(3116). 459–460.

Hall, TL, Barnes, A, Miller, JR, et al. (1993). Neonatal mortality following

transfusion of red cells with high plasma potassium levels. Transfusion. 33(7). 606–609.

Degen, M. (1987). Pseudohyperkalemia in Akitas. J Am Vet Med Assoc.

541–543.


Метрики статей

Завантаження метрик ...

Metrics powered by PLOS ALM

Посилання

  • Поки немає зовнішніх посилань.