The effect of fenbensyl and fenbendazole on the antioxidant status of dogs during experimental invasion with the pathogen toxocariasis



V. V. Stybel, B. V. Gutyj, W. S. Said, Krzysztof Kubiak, Marcin Jankowski, I. A. Maksymovych, Z. A. Guta, T. V. Martyshuk, V. I. Karpovskiy

Анотація


Abstract. The article presents the results of studies of the effect of fenbensyl and fenbendazole on the antioxidant status of dogs in the experimental infestation of the pathogen toxocariasis. The experiments were performed on 18 dogs, two and four months old. Three groups of six animals in each were formed: control and two experimental groups. Puppies of all groups were experimentally infected with the pathogen toxocariasis at a dose of 5,000 invasive T. canis eggs per kg of body weight. The control group of dogs was as untreated control. Puppies of the first experimental group were fed with the drug “Fenbendazole” at a dose of 150 mg per 3 kg of animal weight once a day for three days in a single doze. Puppies of the second experimental group were fed with the drug “Fenbensyl” (TU U 00492990-027: 2020 The drug “Fenbensyl”) at a dose of 350 mg per 3 kg of animal weight once a day for three days. While studying the activity of the enzymatic link of the antioxidant defense system, namely catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, as well as non-enzymatic link: the level of reduced glutathione in animals of experimental groups found an increase in the activity of these indicators. It should be noted that the use of the drug “Fenbensyl” in infected dogs contributed to a better normalization of the antioxidant system in animals than the use of the drug “Fenbendazole”. The use of fenbensyl in infected dogs contributed to a more likely increase in the antioxidant status of the dogs of the second experimental group, as this drug includes milk thistle, which exhibits antioxidant properties due to the presence of silymarin, which restores damaged liver cell cells. Studies confirm the effectiveness of the use of milk thistle in the drug “Fenbensyl” in dogs with the development of toxocariasis invasion to activate the protective systems of their body.

 


Ключові слова


parasitology, pharmacology, dogs, antioxidant system, milk thistle

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