THE INVESTIGATION OF ERITHROCYTES SPHERULATION IN REPRODUCTIVE AND MENOPAUSAL WOMEN

Автор(и)

  • L. R. Ratiani
  • M. A. Dgebuadze
  • N. A. Intskirveli
  • G. L. Ormotsadze
  • T. V. Sanikidze

Анотація

In two groups of 90 women (with dislipidemia, arterial hypertension, obesity, metabolic syndrome and other symptoms) at the age of less than 45 years (repro-ductive age group - 43) and more than 45 years ( menopause age group - 50 ) were investigated the lipid profile (lipid spectrum - LDL, HDL, TC, VLDL, Tg), estrogen content and erythrocytes spherulation index and compared with each other. It was proved the existence of reliable correlation between red blood cells dysfunction indi-

cator, spherulation quality, and atherogenic index Tg/HDL highlights; however, the correlation coefficient is 2 times higher in the reproductive age as in menopause. Spherulation quality of red blood cells at low HDL content showed fast growth rate in reproductive-aged women, and was unsensitive to HDL content in menopasal wom-en. It was concluded that age-related lack of estrogens in menopausal women indi-rectly contributes to decrease protection of red blood cells against oxidative damage, reduces their deformability and disturbances the rheological properties. Spherulation quality of red blood cells may be used as a diagnostic marker of severity of athero-sclerosis.

 

Erythrocytes, aging changes, reproductive age, menopause, spherula-tion of erythrocytes, lipid metabolism, atherogenic index, estrogens.

Біографії авторів

  • L. R. Ratiani
    MD
  • M. A. Dgebuadze
    MD, PHD, ScD, professor
  • N. A. Intskirveli
    MD, PHD
  • G. L. Ormotsadze
    MD, PHD,
  • T. V. Sanikidze
    MD, PHD, ScD, professor

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