THE INVESTIGATION OF ERITHROCYTES SPHERULATION IN REPRODUCTIVE AND MENOPAUSAL WOMEN

Анотація

In two groups of 90 women (with dislipidemia, arterial hypertension, obesity, metabolic syndrome and other symptoms) at the age of less than 45 years (repro-ductive age group - 43) and more than 45 years ( menopause age group - 50 ) were investigated the lipid profile (lipid spectrum - LDL, HDL, TC, VLDL, Tg), estrogen content and erythrocytes spherulation index and compared with each other. It was proved the existence of reliable correlation between red blood cells dysfunction indi-

cator, spherulation quality, and atherogenic index Tg/HDL highlights; however, the correlation coefficient is 2 times higher in the reproductive age as in menopause. Spherulation quality of red blood cells at low HDL content showed fast growth rate in reproductive-aged women, and was unsensitive to HDL content in menopasal wom-en. It was concluded that age-related lack of estrogens in menopausal women indi-rectly contributes to decrease protection of red blood cells against oxidative damage, reduces their deformability and disturbances the rheological properties. Spherulation quality of red blood cells may be used as a diagnostic marker of severity of athero-sclerosis.

Erythrocytes, aging changes, reproductive age, menopause, spherula-tion of erythrocytes, lipid metabolism, atherogenic index, estrogens.