INFLUENCE ALLOGENIC MESENCHIMAL STEM CELLS ON METASTASIS PROCESS IN MICE C57Bl/6 WITH TRANSPLANTANT LEWIS LUNG CARCINOMA



L. V. Kladnytska, A. Y. Mazurkiewich, L. V. Harmanchchuk, S. V. Velichko, O. I. Djus, V. V. Kovpak, O. Y. Dasykevych

Анотація


Influence аllogeneic mesenchymal stem cells in the process of metastasis in mice C57BL/6 with transplant metastatic Lewis lung carcinoma were investigated. Experiments were performed on C57Bl/6 male mice three- week-old, weighing 20-22 g. The process of metastasis in animal control and experimental groups differed significantly. The effect of allogeneic MSCs on process metastasis enters the vascular stage rather certifying a higher number of metastases larger size. The total number of metastases measuring 1.0 - 3.0 mm in the animals of experimental group is 52.5%, while in the control of this indicator - 31.4%. Value of the total volume of metastases by exposure allogeneic MSCs significantly higher 41.52+7.9 * than animals in the control group - 17,94 + 6,59 (P <0.05). The use of MSCs in mice with Lewis lung transplant carcinoma has influence on the increase in the total volume of metastasis (ɳ2x = 0.26, p <0.05).


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