Терапевтична ефективність комплексу амінокислот у хворих за епілепсії собак

М. І. Цвіліховський, О. М. Якимчук, Н. Ю. ІВАНЧЕНКО

Анотація


THERAPEUTIC EFFICACY OF AMINO ACID

COMPOSITION IN EPILEPTIC DOGS

 

M. I. Tsvilikhovskiy, O.M. Yakymchuk, N. Y. Ivanchenko

 

Abstract. The epilepsy is the most widespread chronic neurological disorders among animals, as well as among people. Nevertheless the efficacy and safety of the major part of antiepileptic drugs is not satisfactory. For this reason investigations aimed for elaborating new drugs are still actual. According to scientific literature such amino acids, as leucine, isoleucine, valine, glycine and taurine appears to be promising regarding antiepileptic effect. Result regarding the efficacy of the oral simultaneously administration of mentioned amino acids to epileptic dogs («unknown cause epilepsy» in correspondence to IVETF) are represented in this publication. The experimental group was formed with eight epileptic dogs which during two-mounth period were given amino acids in such daily doses per kilogram divided equally in order to be given every 8 h: L-leucine – 150 mg, L-isoleucine – 275 mg; L- valine – 240 mg; glycine – 300 mg; taurine – 240 mg. The efficacy was estimated by visual detection of paroxysmal activity and quantitative electroencephalography (QEEG) using fast Fourier transformation (FFT) and by monitoring seizure frequency. Clinically antiepileptic effect of amino acid composition was represented by the prolongation of interictal periods per 2 to 3 times in 37,5 % of dogs and by elimination of cluster seizures.


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