Застосування клітинно-асоційованої терапії собакам із гострим панкреатитом





  1. A.  G. Milastnaia


Abstract. The results the study application of cell-associated therapy dogs with acute pancreatitis. It has been found that the introduction of sick animals aprotinin method leukocyte directional transport media leads to normalization of the activity of pancreatic enzymes and eliminates the inflammatory process. The dynamics of the changes of the inflammatory process determined by leukocyte index, the functional state of the pancreas - to help determine its enzymatic activity. It is found that compared with conventional intravenous application of aprotinin, this method provides a more rapid and effective treatment of dogs with acute pancreatitis, in particular by increasing local immunity and, as a consequence, a quick normalization of clinical and laboratory parameters. Use own blood cells as containers for drugs reduces the risk of side effects and risk of pathological immune reactions directed against the drug encapsulated permits modification of the pharmacodynamic and pharmacokinetic parameters of the drug. The use of aprotinin dogs suffering from acute pancreatitis in autologous leukocyte media reduces the multiplicity and duration of the drug significantly reduces the activity of pancreatic enzymes, decreases manifestations of inflammation.

Повний текст:



Shlapak I. P., Mishchenko D. L., Vasilyev G. A. (2004). Acute pancreatitis: prevention and treatment of pancreatic infection. Clinical antibiotics. Vol. 4(30). 1014.

Karpushina I. A., Stebleva T. F., Bonitenko E. J. (2004). Application techniques directed transport of drugs into clinical practice. Rus. Biomed. Jour. Vol. 5(12). 404-408.

Burkovsky M. І., Koval V. I., Verba A.V., Staschuk R. P. (2010). Еxperience with regional intraarterial infusion therapy in treatment of acute pancreatitis Kharkov surgical school. Vol. 5(43). 101-103.

Begdullaev A. K., Mansharipova A.T., Dzhusipov A. K. etc. (2008). Problem targeted transport of drugs into clinical practice. Therapeutic Gazette Vol. 17(1). 32-36

Labro M. T., Benna J. El. (1991). Effects of anti-infectious agents on polymorphonuclear neutrophils. Eur. J. Clin. Microbiol. Infect. Dis. Vol. 10. 124–131.

Gordeev M. S., Tarabarin V. I. (2000). Experience in the treatment of patients with pancreatic necrosis using the method of extracorporeal antibiotic therapy IX All-Russian Congress of Surgeons, a collection of works. 29-30.

Bielski A. N., Potapchuk V. B., Lukin V. V., Plock A. N. (2003). Pharmacokinetics of antimicrobial agents during theorption-apheresis operations extracorporeal detoxification. J. Efferent therapy. Vol. 9(1). 59-59.

Brown A., Baillargeon J. D., Hughes M. D. et al. (2002). Can fluid resuscitation prevent pancreatic necrosis in severe acute pancreatitis? Pancreatology. Vol.2. 104-107.

Метрики статей

Завантаження метрик ...

Metrics powered by PLOS ALM


  • Поки немає зовнішніх посилань.