Патоморфологічні зміни в печінці великої рогатої худоби за дикроцеліозу

М. В. Скрипка, О. В. Кручиненко, М. П. ПРУС




M. V. Skrypka, O. V. Kruchynenko, M. P. Prus


Abstract.According to the results of the investigations was found that at the low level of dicrocoeliosis infestation of the liver (average 49.6 ± 3,1samples), outside the latter was no visible changes. In the context of a lumen of the bile ducts were found Dicrocoelium species. At histologic examination were found liver cell infiltration of interlobular connective tissue. More intense was the cellular infiltration of the connective tissue located around the bile ducts. There were registered mucoid edema and swelling of the fibers. In some bile ducts wall hyalinosis of mucosa was registered. In some ducts lumen was clearly visible as helminths, and their fragments.

Histologic examination of the liver cell infiltration found interlobular connective tissue. The composition infiltrations are unstable, in some areas dominated by granulocytes on the other - lymphoid cells and fibroblasts from a number located between singly granulocytes. More intense is the cellular infiltration of the connective tissue located around the bile ducts. Infiltrates these areas consist mainly of granulocytes (neutrophils, eosinophils and some monocytes), except that in view recorded lymphocytes and fibroblasts.

The study found liver lobules uneven expansion gaps and capillary blood supply interparticles sinusoid. Hepatocytes with moderate signs of granular dystrophy, the cells are in a state of decomposition of fat. Register cell in which hepatocytes with signs parameters and necrosis of hepatocytes contours is not clear, and in some cases are near cell merging into an amorphous mass, which can hardly trace remains of nuclei. Connective tissue such sites in the state of edema, contains rare eosinophils. In the field of small cells found with signs of proliferation, consisting mainly of lymphocytes andfibroblasts. Replacement of individual hepatocytes fibroblasts leads to disruption of the girder structure hepatocytes. The above connective tissue cells located between hepatocytes, leading to atrophy of parenchymal cells. Hepatocytes and their nuclei decrease in volume, the cytoplasm more intense pink color.

Mechanical action of mature dicrocoelias, and the impact of toxic metabolic products of agents to the mucosa of bile ducts leads to mechanical destruction of epithelial hyperplasia and metaplasia. Focal lymphocytic infiltrates can testify in favor of the immune response in animal organism on agents and hyperplasia and metaplasia epithelium of the bile ducts is a compensatory process to new conditions of existence authority in collaboration with D. lanceatum. No symptoms of cirrhosis indicates the low intensity of Dicrocoelium infestation of the liver was revealed.

Повний текст:



Horalskyi L. P., Khomych V. T., Kononskyi O. I. (2005). Osnovy histolohichnoi tekhniky i morfofunktsionalni metody doslidzhennia u normi ta pry patolohii [Histological techniques and morphological methods in normal and pathological conditions]. Zhytomyr: Polissia, 288. (in Ukraine)

Gorshkova G. G. (2004). Dikrotselioz krupnogo rogatogo skota v Respublike Tatarstan (epizootologiya, diagnostika i terapiya) [Dicroceliasis cattle in the Republic of Tatarstan (epizootiology, diagnosis and therapy)]. Nizhny Novgorod State Agricultural Academy, 22. (in Russia)

Dakhno I. S. (2001). Epizootolohiia, patohenez, etiotropna ta imunokoryhuiucha terapiia pry fastsiolozi i dykrotseliozi zhuinykh tvaryn [Epizootology, pathogenesis, and imunocorrection therapy for Fascioliasis and Dicroceliasis ruminants]. Observed Inst. and Clinic. vet. Medicine UAAS . Kharkiv, 36. (in Ukraine)

Zon H. A., Skrypka M. V. (2009). Ivanivska Patolohoanatomichnyi roztyn tvaryn [Mortem animals]. Donetsk, 190. (in Ukraine)

Latyipov D. G., Lutfullin M. H., Gaysin G. N., Gorshkova G. G. (2002). Epizooticheskaya situatsiya po dikrotseliozu krupnogo rogatogo skota v Respublike Tatarstan [Epizootic situation dicroceliasis cattle in the Republic of Tatarstan]. Veterinarnyiy vrach, № 1(9), 16 -18. (in Russia)

Mantaeva S. Sh., Aliev Sh. K. (2011). Rasprostranenie dikrotselioza krupnogo rogatogo skota v prirodno-klimaticheskih zonah Chechenskoy respubliki [Distribution dicroceliasis cattle in climatic zones of the Chechen Republic]. Theory and practice of parasitic diseases of animals, N 12, 295 - 299. (in Russia)

Mkrtchyan M. E., Vasilev Yu. G., Troshin E. I. Proyavlenie tsitoliticheskogo sindroma u byichkov pri trematodozah i ih assotsiatsii [Cytolytic manifestation syndrome in trematodosis and their associations of bulls]. Ouch. Rec. Kazan State Academy of Veterinary Medicine. NE Bauman, N 4, T. 220, 168 - 171. (in Russia)

Sánchez-Campos S1, González P, Ferreras C, García-Iglesias M. J. González-Gallego J, Tuñón MJ. (2000). Morphologic and biochemical changes caused by experimentally induced dicroceliosis in hamsters (Mesocricetus auratus). Comp Med., 50(2):147-152.

Kohler P., Hanselmann K. (1973). Intermediary metabolism in Dicrocoelium dendriticum (Trematoda). Comp. Biochem. Physiol. Vol. 45. N 3, 825 - 845.

Kohler P., Stahel O.F. (1972) Metabolic end products of anaerobic carbohydrate metabolism of Dicrocoelium dendriticum (Trematoda). Comp. Biochem. Physiol, Vol. 43, N 3, 733 - 741.

Метрики статей

Завантаження метрик ...

Metrics powered by PLOS ALM


  • Поки немає зовнішніх посилань.