Evaluation of exogenous effects of carbohydrate and ethanol solutions on rat liver
DOI:
https://doi.org/10.31548/bio2019.05.003Keywords:
liver, glucose, ethanol, blood, rats, pathological processAbstract
The results of studies of exogenous action of glucose and ethanol solutions on the rat organism with description and demonstration of pathological changes of the liver are presented in the article.
Prolonged action of ethanol and its metabolism products on the liver, especially acetaldehyde, and under conditions of enhancement by other factors (for example, carbohydrate solutions), leads to impaired function and causes significant morphological changes. Morphofunctional disorders of the liver, in turn, can provoke some serious animal complications, one of which is type 2 diabetes. This is due to the crucial role of the liver in the regulation of carbohydrate metabolism.
Type 2 diabetes became a widespread disease in pets in recent years, which is primarily related to their diet. The effects of this disease are reduced productivity, stunted growth and high early mortality in animals.
A study of one of the most important indicators of carbohydrate metabolism - serum glucose content, showed that animals that regularly consumed a carbohydrate solution (by drinking way) for 23 days had a 54% increase in blood glucose, while in rats with additional alcohol load in the diet (ethanol solution in combination with glucose solution) - by 77% compared to control.
Carrying out histological studies in experimental animals revealed the development of pathological changes, which depending on the conditions of the experiment had different severity. In particular, when consuming carbohydrate solution by drinking way, the animals developed: granular hepatocyte dystrophy and histiocytic infiltration of the interparticle connective tissue. In animals treated with a carbohydrate solution in combination with ethanol, granular and hyaline-drip hepatocytes, histiocytic infiltration of the interparticle connective tissue, and cholestasis in the bile ducts were detected.
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