THE BIOCHEMICAL MECHANISM OF RESTORATION OF ACID-ALCALINE HOMEOSTASIS OF NEWBORN (UNDER ENTEROPATHOLOGY) CALVES, THEIR CORRECTION

Authors

  • D.O. Melnychuk ,
  • V.A. Gryshchenko

Abstract

The results of the study of the biological regularities formation of the acid-base homeostasis of the organism in the calves that are one month old, including recovered from neonatal enteropathology calves are summarized in this publication.

The parameter stabilization of the blood acid-base balance in the calves occurs during the first 24–36 hours of life involving the excretory organs (lungs, alimentary tract, kidney), blood buffer systems and metabolic system of the acid-base homeostasis (through the change of the direction and intensity of the metabolism processes).

With the nascence of the dyspepsia symptom the bicarbonate and buffer bases concentration decreases and the blood active reaction shifts to the acid side in the calf blood. This is accompanied by the development of the metabolic acidosis of varying severity. The increase of the pCO2 in blood of such animals is observed. Herewith, the excessive formation of protons in the intracellular environment as a result of the tissue hypoxia is revealed. The oxygen deficiency in the tissues leads to the inhibition of the H+ ions neutralization by the water formation; to the excessive lactate production as a result of the activation of anaerobic glycolysis; to the increase of the acids formation. Among these acids beta-hydroxybutyric and acetoacetic acid are of the most importance. Following intensive rise of the proton concentration in the internal environment of the organism of affected animals is explained by the emergence of the hemic hypoxia (a lack of the hemoglobin buffer system). It leads to the disturbances in the gas exchange and diffusion at the alveolar and tissue capillaries and to the functional disorders of the kidneys. The last is revealed through the insufficient excretion of non-volatile acids through the urinary system. This state of the organism requires to be corrected.

The biochemical mechanisms that have been a basis for the development and practical use of the liposomal form of the biologically active supplement «FLP-MD» from milk phospholipids in veterinary medicine in case of the neonatal enteropathology of non-contagious etiology in the newborn calves are described.

Downloads

Issue

Vol. 5 No. 5-6 (2013): (англ)

Section

Статті

License

Relationship between right holders and users shall be governed by the terms of the license Creative Commons  Attribution – non-commercial – Distribution On Same Conditions 4.0 international (CC BY-NC-SA 4.0):https://creativecommons.org/licenses/by-nc-sa/4.0/deed.uk

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).