Effect of mesenchymal stem cells in reparative osteogenesis in animals
DOI:
https://doi.org/10.31548/bio2017.01.010Abstract
Investigated correlation structure of bone and regenerate fibrinous in rabbits during treatment with allogeneic mesenchymal bone marrow stem cells to correct reparative process in the tissue of animals.Found that the experimental group of animals regeneration of bone in the defect area occurred much faster and better than animals in the control group. These are the facts: regenerate a large area compared to animals in the control group; more pronounced development periosteum compared to animals in the control group; greater intensity of calcium deposits compared to animals in the control group; no pathological changes (histiocytic infiltration of fibrous connective tissue, vascular congestion) than animals in the control group.
Keywords: mesenchymal stem cells, bone regenerateReferences
Mazurkevych A. I., Kharkevych Yu. O., Maliuk M. O., Danilov V. B., Kovpak V. V., Zhurba V. I. (2010). Vplyv mezenkhimalnykh stovburovykh klityn kistkovoho mozku ta embrionalnykh fibroblastiv shchuriv na perebih reparatyvnykh protsesiv u yikhniishkiri. [Influence of mesenchymal barrel cages of marrow andembryo desmocytes of rats is on motion of репаративнихprocesses in their skin] Naukovyi visnyk Natsionalnoho universytetu bioresursiv i pryrodokorystuvannia Ukrainy, 151,Ch 1.- S.197-205. (in Ukraine)
Mazurkevych A.I., Maliuk M.O., Tkachenko S.M., Kharkevych Yu.O.(2014). Vyvchennia biosumisnosti hemostatychnykh hubok iz stovburovymy klitynamy kistkovoho mozku krolia pid chas kultyvuvannia in vitro [Study of biocompatibility of гемостатичних sponges with thebarrel cages of marrow of кроля during cultivation of in vitro] Visnyk Sumskoho natsionalnoho ahrarnoho universytetu, Vyp.1(34), S. 7 - 11. (in Ukraine)
Mazurkevych A.I., Maliuk M.O., Danilov V.B. (2012). Metodychni rekomendatsii «Vykorystannia mezenkhimalnykh stovburovykh klityn dlia korektsii reparatyvnykh protsesiv v orhanizmi tvaryn-retsipiientiv» [Methodical recommendations "Use of mesenchymal stem cells for the correction of reparative processes in the organism of animals-recipients". ]. Kyiv, S. 42. (in Ukraine)
Aggarwal S., Pittenger M.F. (2005). Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood, 105, 1815-1822.
https://doi.org/10.1182/blood-2004-04-1559
Augello A., Tasso R., Negrini S.M. (2005). Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur. J. Immunol, 35, 1482-1490
https://doi.org/10.1002/eji.200425405
Mangashetti L. S. (2005). IL-4 inhibits bone-resorbing activity of mature osteoclasts by affecting NF-kappa B and Ca2+ signaling J. Immunol, Vol. 175, 917-925.
https://doi.org/10.4049/jimmunol.175.2.917
Niemeyer P.,Krause U.,Kasten P. (2006). Mesenchymal Stem Cell-Based HLA-Independent Cell Therapy for Tissue Engineering of Bone and Cartilage. Current Stem Cell Research and Therapy, Vol. 1: 1, 21-27.
https://doi.org/10.2174/157488806775269151
Quarto R., Mastrogiacomo M., Cancedda R., Kutepov S.M., Mukhachev V., Lavroukov A., Kon E., Marcacci M. (2001). Repair of large bone defects with the use of autologous bone marrow stromal cells. N. Engl. J. Med.- Vol. 344, N 5. - P. 385-386.
https://doi.org/10.1056/NEJM200102013440516
Roodman G. D.(1993). Role of cytokines in the regulation of bone resorption. Calcif. Tissue Int.,Vol. 53: 1, 94-98.
Downloads
Published
Issue
Section
License
Relationship between right holders and users shall be governed by the terms of the license Creative Commons Attribution – non-commercial – Distribution On Same Conditions 4.0 international (CC BY-NC-SA 4.0):https://creativecommons.org/licenses/by-nc-sa/4.0/deed.uk
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).