Screening investigation of antibacterial action of new oxiamin derivatives

Authors

DOI:

https://doi.org/10.31548/bio2017.03.001

Abstract

The aim of research was to evaluate the antimicrobial activity of 53 new synthesized oxiamine compounds. These substances were investigated for the first time in to the antibacterial activity against museum strains of gram-positive and gram-negative bacteria, including representatives of the "ESCAPE" pathogens: Enterococcus, Staphylococcus, Klebsiella, Pseudomonas. Evaluation of antibacterial action of the substances was establishing by determining their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). A number of substances that have shown concentratio- and structure-dependent antimicrobial activity against pathogenic and conditionally pathogenic gram-positive and gram-negative bacteria were identified among the studied groups of new oxiamine derivatives. Among group of adamantane containing compounds identified compound № 11 – 1-(adamantan– 1–methoxy)–3-(2,2,6,6–tetramethylpiperidine)- 2-propanol hydrochloride. MBC of compound № 11 towards S. aureus was 5,6 mg/ml. The MBC of compound № 11 towards Ps.aeruginosa and Kl.pneumoniae was in the same range as that of the comparison drug ofloxacin (62,5 μg/ml and 7.8 μg/ ml, respectively).

Keywords: oxiamine derivatives, antibacterial activity, "ESKAPE" pathogens

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Published

2017-07-27

Issue

Vol. 9 No. 3-4 (2017)

Section

Biology

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