STATE OF GLUTATHIONIC LINK OF ANTIOXIDANT SYSTEM IN BLOOD OF RATS UNDER CONDITIONS OF OXIDATIVE STRESS AND FOR THE ACTION OF LIPOSOMAL DRUG «BUTASELMEVIT»
Abstract
The article contains the results of search of the influence of the developed complex liposomal drug «Butaselmevit» on the activity of glutathione system of antioxidant protection in the blood of rats under condition of simulated oxidative stress, caused by the use of carbon tetrachloride.
It is proved that intramuscular injection to rats of experimental group 50% of oil solution tetrachloromethane at a dose of 0.25 ml per 100 g of body weight of animal, causes antigenic load on the body and leads to inhibition of the activity of glutathione system of antioxidant protection of the rats body. This indicates the low activity of glutathione peroxidase and the low level of restored glutathione in the blood of rats.
To enhance the system activity of antioxidant protection for the development of oxidative stress it is advisable to use the liposomal drug «Butaselmevit», which in its structure contains butafosfan, selenium, methionine, milk thistle and vitamins.
It was set up that parenteral injection to rats for the development of oxidative stress of liposomal drug «Butaselmevit» leads to increase activity of glutathione peroxidase and restored glutathione levels in the blood of rats from the experimental group.
The indicated research results show the antioxidant properties of the new liposomal drug «Butaselmevit.»
Keywords: oxidative stress, rats, carbon tetrachloride, glutathione peroxidase, restored glutathione, liposomal drug «Butaselmevit»
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