STAPHYLOCOCCUS AUREUS AND FUNGI OF GENUS CANDIDA SENSITIVITY TO ADAMANTYL-BASED DERIVATIVES OF AMINOPROPANOL-2
Abstract
The aim of the study was to determine the sensitivity of the museum and clinical strains of staphylococci and fungi of the genus Candida to 27 new adamantylbased derivatives of aminopropanol-2. An antibacterial and antimycotic action of the substances was evaluated according to the minimum inhibitory concentration (MIC) and to the minimum bactericidal or fungicidal concentrations (MBcC or MFcC), which were determined by the micro-method of sequential serial dilutions in a liquid nutrient medium. A museum strain and 10 clinical isolates of Staphylococcus aureus, as well as 5 museum strains and 6 clinical isolates of fungi of the genus Candida are used in the study. As a result of the studies, the significant antimycotic properties in compounds №№1, 6, 10, and 23 were revealed. The MIC of these substances in relation to the museum strains and clinical isolates of Candida species were in the range from 7.8μg/ml to 62.5μg/ml. Substances №6 and №10 showed a moderate effect on staphylococci also. The MIC of compounds, highly active against museum test strains of microorganisms in most cases were equal to the value of the MIC of these substances for clinical isolates of staphylococci and fungi of the genus Candida. Analysis of the antimicrobial activity of substances depending on their chemical structure allowed to put forward a number of assumptions about the influence of some radicals on the presence of antimicrobial properties in the investigated substances.
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