GLOBAL INTEGRATION AND COMMUNICATION BASICS OF COMBATING ANTIBIOTIC RESISTANCE OF MICROORGANISMS
DOI:
https://doi.org/10.31548/dopovidi2017.04.007Keywords:
antibiotic resistance, microorganisms, antibiotics, animal husbandry, food safetyAbstract
In the production of livestock products with therapeutic and prophylactic purpose, use antimicrobial drugs. Over time, pathogenic microorganisms develop mechanisms for adaptation to the negative effects of antibiotics. This phenomenon is called the acquisition of antibiotic resistance by a microorganism. At the global level, the question arises about the addiction of pathogenic microorganisms to certain types of antibiotics. The mechanism of addiction of pathogenic microorganisms to the use of antibiotics gave a significant impetus to pharmacologists to obtain our antimicrobial drugs.
Aim: to investigate the current world experience in the study of the spread of antibiotic resistance pathogenic microorganisms and the main integration and the communication principles of combating this phenomenon.
Results. The paper discusses the analysis of monitoring results under the auspices of the OIE for the dissemination of antibiotic-resistivity of microorganisms in 2013-1016. A parallel between the emergence of new antibiotics on the world veterinary market and the acquisition of the resistance of pathogenic microorganisms to new antimicrobial dosage forms have been made. The main causes of distribution and principles of struggle against antibiotic resistance of pathogenic microorganisms are highlighted.
Attention is drawn to the fact that the increase of the industrial production of livestock products in Ukraine, the increase in the intensity of international trade in agricultural products, the large number of internally displaced persons, the migration of people, birds, and terrestrial wildlife contribute to the intensification of the issue of combating the spread of antibiotic resistant pathogenic microorganisms.
It is suggested that the global problem of antibiotic resistance of pathogenic microorganisms at the present stage is controlled only in two ways, namely, legislative regulation of the circulation and use of antibiotics and the collection of information on the use of antimicrobial drugs in various fields of human activity. Regarding the monitoring of the presence and migration of antibiotic resistant strains of microorganisms, this issue is dealt with in varying degrees only in developed countries. This necessitates the adoption of a national program for controlling the circulation of antibiotics and the spread of antibiotic-resistant pathogenic microorganisms.
The development of a national program to combat the spread of antibiotic resistant strains of microorganisms in Ukraine should be based on the principles of WHO and OIE, but the deduction of the peculiarities of our domestic legislation, livestock production, pharmacological and laboratory facilities is of key importance.
References
Hadzalo Ya.M., Hladiy M.V., Sabluk P.T. (2016) Ahrarnyy potentsial Ukrayiny: monohrafiya. [Agrarian potential of Ukraine: monograph.]. K. : Ahr. Nauka, 332.
Ushkalov V.O., Danchuk V.V., Baranov Yu.S. et al (2016) Monitorynh bioresursiv i produktsiyi ahropromyslovoho kompleksu na pokaznyky yakosti ta bezpeky yak skladova kontseptsiyi VOOZ-MEB "Hlobal'ne zdorov'ya" [Monitoring of bioresources and agro-industrial products for quality and safety indicators as part of WHO-WHO concept "Global health"]. Veterynarna medytsyna, 102, 219-223.
Pro derzhavnu systemu biobezpeky pry stvorenni, vyprobuvanni, transportuvannita vykorystanni henetychno modyfikovanykh orhanizmiv : Zakon Ukrayiny vid 31 travnya 2007 roku #1103-V iz nast. Zminamy. [About the state system of biosafety during the creation, testing, transportationand use of genetically modified organisms], (2007). Vidomosti Verkhovnoyi Rady Ukrayiny (VVR), 35, 484
Aleksandrov D.K., Kryzhanivs'ka O.O., Sydorenko O.O. et al. (2016). Efektyvnyy ahrobiznes [Effective agribusiness]. Kyiv: Vydavnychyy dim «KYY», 152.
Panorama ahrarnoho sektora Ukrayiny [Panorama of the agrarian sector of Ukraine] (2017). Ministerstvo ahrarnoyi polityky ta prodovol'stva, DU «Instytut ekonomiky ta prohnozuvannya NAAN Ukrayiny, HO «Tsentr ahrarnykh reform», 36.
Statystychnyy zbirnyk: Tvarynnytstvo Ukrayiny 2016 rik [Statistical collection: Animal husbandry of Ukraine in 2016] (2017). Derzhavna sluzhba statystyky Ukrayiny,141.
Feshchenko Yu.I., Humenyuk M.I., Denysov O.S. (2010). Antybiotykorezystentnist' mikroorhanizmiv. Stan problemy ta shlyakhy yiyi vyrishennya [Antibiotic resistance of microorganisms. State of the problem and ways of its solution]. Ukrayins'kyy khimioterapevtychnyy zhurnal, 1 (23), 4-10.
Pruden, A., Larsson, D. J., Amézquita, A., Collignon, P., Brandt, K. K., Graham, D. W., ... & Topp, E. (2013). Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment. Environmental health perspectives, 121(8), 878.
https://doi.org/10.1289/ehp.1206446
Gelband, H., Molly Miller, P., Pant, S., Gandra, S., Levinson, J., Barter, D., ... & Laxminarayan, R. (2015). The state of the world's antibiotics 2015. Wound Healing Southern Africa, 8(2), 30-34.
Moroz Ye.D., Blyznyuk M.D., Roshchin H.H., Krylyuk V.O., Kuz'min V.Yu., Novikov F. M., Ivanov V. I. (2017) Ryzyk-oriyentovanyy pidkhid v strukturi indykatyvnoho planuvannya v systemi medychnoho zakhystu naselennya Ukrayiny pid chas nadzvychaynykh sytuatsiy viys'kovoho kharakteru [Risk-oriented approach in the structure of indicative planning in the system of medical protection of the population of Ukraine during emergencies of a military character]. Kadrova polityka u sferi okhorony zdorov"ya v umovakh zahroz natsional'niy bezpetsi Ukrayiny. Materialy shchorichnoyi Vseukrayins'koyi naukovo - praktychnoyi konferentsiyi za mizhnarodnoyu uchastyu ( Kyyiv , 23 bereznya 2017 r.).Kyiv, 112-114.
Kosenko M.V., Muzyka V.P., Kosenko Yu.M., Stets'ko T.I. (2007). Ratsional'ne vykorystannya antymikrobnykh preparativ yak faktor strymuvannya rozvytku antybiotykorezystentnosti [Rational use of antimicrobial drugs as a factor inhibiting the development of antibiotic resistance]. Vet. medytsyna Ukrayiny, 8, 40-41.
Aarestrup, F. (2012). Sustainable farming: Get pigs off antibiotics. Nature, 486(7404), 465-466.
https://doi.org/10.1038/486465a
Todosiychuk T.S., Strelets' T.I., Konopats'ka S.V. (2011). Pidvyshchennya stiykosti mikrobnykh patoheniv yak faktor rozrobky novykh antyseptykiv [Increasing the stability of microbial pathogens as a factor in the development of new antiseptics] Naukovi visti NTUU "KPI", 3, 90-97.
Joint FAO/OIE/WHO expert workshop on non-human antimicrobial usage and antimicrobial resistance: scientific assessment. Food and Agriculture Organization of the United Nations / World Organisation for Animal Health / World Health Organization. 2003. Available at:
http://apps.who.int/iris/bitstream/10665/68883/1/WHO_CDS_CPE_ZFK_2004.7.pdf?ua=1 , accessed 10 April 2017.
WHO publishes list of bacteria for which new antibiotics are urgently needed 27 February 2017 GENEVA. Available at:
http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/
Lewis, K. (2013). Platforms for antibiotic discovery. Nature reviews Drug discovery, 12(5), 371-387.
https://doi.org/10.1038/nrd3975
Danchuk V., Ushkalov V., Slyusar N. (2017). Antybiotykorezystentnist' mikro- ta makroorhanizmu [Antibiotic resistance of micro- and macroorganisms]. Ahrarna nauka ta osvita Podillya, 1, 322-325.
Salmanov A.H., Mariyevs'kyy V.F., Boyko V.V., Ioffe I.V., Taraban I.A. (2012). Antybiotykorezystentnist' v khirurhiyi. [Antibiotic resistance in surgery: Monograph]. Kh.:NTMT, 456.
Williams, A. C. (2016). Applied Epidemiology of Infectious Diseases in Western Australia. Available at: https://openresearch-repository.anu.edu.au/bitstream/1885/101009/1/Williams%20Thesis%202016.pdf
Pulcini, C., Wencker, F., Frimodt-Møller, N., Kern, W. V., Nathwani, D., Rodríguez-Baño, J., ... & ESGAP Curriculum Working Group. (2015). European survey on principles of prudent antibiotic prescribing teaching in undergraduate students. Clinical Microbiology and Infection, 21(4), 354-361.
https://doi.org/10.1016/j.cmi.2014.11.015
Health authorities worry that these superbugs will become unstoppable. By Teresa Carr January 19, 2017. Available at: http://www.consumerreports.org/overuse-of-antibiotics/dangerous-antibiotic-resistant-bacteria-spreading/
Kotsyumbas I.Ya., Muzyka V.P., Stets'ko T.I. (2014). Stan antybiotykorezystentnosti mikroorhanizmiv - zbudnykiv bakterial'nykh zakhvoryuvan' molodnyaku velykoyi rohatoyi khudoby i svyney. [Condition of antibiotic resistance of microorganisms - pathogens of bacterial diseases of young animals of cattle and pigs]. Naukovyy visnyk veterynarnoyi medytsyny, 13 (108), 117-120.
Crump J. A. (2011). Antimicrobial resistance among invasive nontyphoidal Salmonella enterica in the United States, national antimicrobial resistance monitoring system, 1996-2007 Antimicrobial agents and chemotherapy Available at: http://aac.asm.org/content/early/2011/01/03/AAC.01333-10.full.pdf.
https://doi.org/10.1128/AAC.01333-10
Allegranzi, B., Nejad, S. B., Combescure, C., Graafmans, W., Attar, H., Donaldson, L., & Pittet, D. (2011). Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. The Lancet, 377(9761), 228-241.
https://doi.org/10.1016/S0140-6736(10)61458-4
National Antimicrobial Resistance Surveillance Thailand (NARST). Antimicrobial Resistance 2000-2016 Available at: http://narst.dmsc.moph.go.th/data/AMR%202000-2016.pdf
OIE Annual report on the use of antimicrobial agents in animals. BETTER UNDERSTANDING OF THE GLOBAL SITUATION. 2016. Available at: http://www.oie.int/fileadmin/Home/fr/Our_scientific_expertise/docs/pdf/AMR/Survey_on_monitoring_antimicrobial_agents_Dec2016.pdf
State of the World"s Antibiotics, 2015. Center for Disease Dynamics, Economics & Policy. (2015). CDDEP: Washington, D.C.,79.
.World Health Organization et al. Global action plan on antimicrobial resistance. (2015). Available at: http://www.wpro.who.int/entity/drug_resistance/resources/global_action_plan_eng.pdf
House W. (2015). National action plan for combating antibiotic-resistant bacteria. The White House, Washington, DC. Available at: https://obamawhitehouse.archives.gov/sites/default/files/docs/national_action_plan_for_combating_antibotic-resistant_bacteria.pdf
World Health Organization et al. Global action plan on antimicrobial resistance. 2015. (2017). Vol. 978: 924, 150976.
World Health Organization et al. Antimicrobial resistance: global report on surveillance. (2014). World Health Organization, 256. Available at: http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf
World Health Organization et al. Critically important antimicrobials for human medicine: ranking of antimicrobial agents for risk management of antimicrobial resistance due to non-human use. (2017). World Health Organization.
Mc Nulty, K., Soon, J. M., Wallace, C. A., & Nastasijevic, I. (2016). Antimicrobial resistance monitoring and surveillance in the meat chain: A report from five countries in the European Union and European Economic Area. Trends in Food Science & Technology, 58, 1-13.
Downloads
Published
Issue
Section
License
Relationship between right holders and users shall be governed by the terms of the license Creative Commons Attribution – non-commercial – Distribution On Same Conditions 4.0 international (CC BY-NC-SA 4.0):https://creativecommons.org/licenses/by-nc-sa/4.0/deed.uk
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
