The effect of testosterone on the bile acid and bile lipid composition in rats
DOI:
https://doi.org/10.31548/dopovidi2021.05.003Keywords:
testosterone, bile, bile acids, lipids, liverAbstract
The study of sexual differences in the regulation of exocrine liver function is one of the topical areas in hepatology. After all, the liver serves as a mediator in a number of systemic effects of sex hormones on the body and is a key organ of their metabolism. In particular, the correlation between the concentration of steroid hormones can determine the direction of physiological processes and their possible distortions.
Methods: physiological, biochemical, methods of mathematical statistics.
Cholesecretion increased in female rats under the influence of testosterone. Testosterone raised the concentration of taurocholic acid and at the end of the acute experiment the level of taurohenodeoxycholic and taurodeoxycholic acids significantly increased. By comparison, the content of glycocholates decreased significantly immediately after the administration of the hormone but at the end of the experiment, the content of glycocholic acid increased significantly. The level of free bile acids increased under the testosterone. Testosterone affected the bile lipid composition, in particular, it raised the concentrations of phospholipids, cholesterol and its ethers, while the content of free fatty acids decreased under the studied hormone.
Testosterone when administered intraperitoneally to female rats significantly affects the concentration of conjugated and free cholate, which may indicate its involvement in metabolic transformations and transport of bile acids to the primary bile ducts. The studied hormone raised the concentration of phospholipids, cholesterol and its ethers, but reduced the content of free fatty acids in the liver secretion of the studied animals.
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