INTENSITY OF LIPID OXIDATION AND OXIDATIVEMODIFICATION OF PROTEINS IN BLOOD OF RATS UNDER THE CONDITIONS OF CHRONIC INFLUENCE OF MIXTURE OF NANO PARTICLESOF METALS AND THEIR MACRO-DISPERSE ANALOGUE
DOI:
https://doi.org/10.31548/dopovidi2017.05.008Keywords:
antioxidant system, metal nanocomposite, oxidative modification of proteins, lipid peroxidation, metal salts, plasma, chronic toxicity, ratsAbstract
In this article we studied the chronic oral effects of the NPMe mixture (Ag, Cu, Fe, Mn dioxide) in comparison with its macro-dispersed analogue on the intensity of oxidative processes in the blood of white rats. Research has established that chronic oral reception of a mixture of metals in various disperse forms caused in the blood of experimental rats different-directional changes in the formation of products of lipoperoxidation in the dynamics of the experiment. All animals were monitored for 90 days (main period). On the 15th, 30th and 60th day after the start of feeding, and in 30 days after termination of feeding (on the 90th day) the mixture of NPMe and metal salts, there were taken blood samples from 5 animals from each group after inhalation chloroform anesthesia. After that blood plasma was obtained for biochemical studies.Regarding results of strengthening the endogenous AOA against the background of storage of physiological levels of the intensity of the processes of LPO and OMB in experimental rats under the action of a mixture of NPMe in a dose of 0.3 mg/kg of body weight, it can be argued about its antioxidant effect, and in subsequent studies it can be taken into account for the purpose of creation nanonutraceutical of adaptogenic orientation.
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