Features of the immunogenetic structure of pigs of domestic breeds, suitable for xenotransplantation
DOI:
https://doi.org/10.31548/dopovidi2022.01.002Keywords:
erythrocyteantigen, polymorphism, allele, pigs, immunogenetic profile, xenotransplantationAbstract
The comparative assessment of the immunogenetic status of pigs of the Ukrainian meat-type and Myrgorod pigs has been carried out. The specificity of immunogenic profiles has been evaluated, depending on the history of creation and the direction of the productivity of animals. It has been found out that 24 specimens of Myrhorod pigs and 13 specimens of the Ukrainian meat-type pigs have the presence of genotypes А-/- and Еbdgkmp/ bdgkmp which determine the suitability of animals for xenotransplantation. The Ukrainian meat-type pigs and Myrgorod pigs had the largest differences in the distribution of alleles by B, E, F, K, L blood group systems with the presence of the Ladhjk marker allele in the specimens of Myrgorod pigs. (p <0.05).
The possibility of occurrence of reproductive and resistance disorders of pigs in the selection by blood groups genotypes modeled for xenotransplantation and the search for ways to their selection overcoming are discussed.
References
Martyinenko, N.A. (2006). Svinya kak model v biomeditsinskih issledovaniyah. Ksenotransplantatsiya (obzor). [A pig as a model in biomedical research. Xenotransplantation (overview)]. Visnyk Poltavskoi derzhavnoi ahrarnoi akademii. Bulletin of Poltava State Agrarian Academy. 2:181-188 (in Ukrainian).
Zinoveva, N.A., Melerzanov, A.V., Petersen, E.V., Klimyuk, N.N., Volkova, N.A., Duh, A.S., Trusova, I.A., Volf, E. and G. Brem. (2014). Ispolzovanie transgennyih GAL-KO sviney v ksenotransplantatsii: problemyi i perspektivyi. [The use of transgenic GAL-KO pigs in xenograft: problems and prospects]. Selskohozyaystvennaya biologiya – Agricultural biology. 2:42-49 (in Russian).
Stankova, N.V. (2009). Immunobiologicheskiy status sviney i vozmozhnosti ispolzovaniya ih v tselyah ksenotransplantatsii: diss. na soisk. uch. step. kandidata biol. Nauk. [Immunobiological status of pigs and the possibility of using them for xenograft purposes: dissertation for the degree of candidate of biological sciences]. 140 (in Russian).
Tihonov, V.M. (1991). Immunogenetika i biohimicheskiy polimorfizm domashnih i dikih sviney. [Immunogenetics and biochemical polymorphism of domestic and wild pigs]. 300 (in Russian).
Rybalko, V.P., Berezovskyi, M.D., Bohdanov, H.A. et al. (2005). Suchasni metodyky doslidzhen u svynarstvi. [Modern research methods in pig production]. 228 (in Ukrainian).
Peacall, R. and P.E. Smouse. (2006). GENALEX 6: genetican alisys in Excel Population genetics of twarean dresearch. Molecula Ecology Notes. 6:288–295 (in English).
Plohinskiy, N. A. (19690) Rukovodstvo po biometrii dlya zootehnikov. [Biometrics Guide for Livestock]. 255 (in Russian).
Suhova, N.O., Bekenev, V.A., Kolomnikov V.A. et al. (1989). Svyaz grupp krovi s otkormochnyimi i m’yasnimi kachestvami sviney. [The relationship of blood groups with feed and meat qualities of pigs]. Dokladyi VASHNIL Reports of Lenin All-Union Academy of Agricultural Sciences. 2: 24-26 (in Russian).
Downloads
Published
Issue
Section
License
Relationship between right holders and users shall be governed by the terms of the license Creative Commons Attribution – non-commercial – Distribution On Same Conditions 4.0 international (CC BY-NC-SA 4.0):https://creativecommons.org/licenses/by-nc-sa/4.0/deed.uk
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
