GENETIC CAUSALITY OF DOGS CARDIOVASCULAR DISEASES
Abstract
Endocardiosis mitral valve is the most common cardiac disorders in dogs, especially small breeds. The possible genetic mechanisms of hereditary predisposition to diseases of the cardiovascular system in dogs. Diseases of the small breeds can be caused by a mutation of the gene IGF1, which is one of the main reasons for the decline in body size in dogs. Distribution endocardiosis mitral valve may be due to the fact that mutations that cause arising portions that are closely linked to the gene candidate small dogs STC2, which has a value selectively. Since this gene is closely linked site NKX2 -5, mutations in which are
linked with numerous congenital heart disease.
References
Руденко А.А. Поширеність та етіологічна структура серцево-судинних хвороб у собак / А.А.Руденко, М.І.Цвіліховський // Ветеринарна медицина України.- 2009.-№ 10.- С.13-15.
Мартин М., Коркорэн . Кардиореспираторные болезни собак и кошек.
- М.: Аквариум, 2004.- С. 54-86.
Клименко А.В. Диагностика и лечение эндокардиоза митрального
клапана у собак / А.В Клименко // Мир ветеринарии. – 2014.- №1. – С.
-33.
Parker HG1, Kilroy-Glynn P. Myxomatous mitral valve disease in dogs:
does size matter? / Parker HG1, Kilroy-Glynn P.// J Vet Cardiol. 2012
Mar;14(1).- P. 19-29.
Genetic basis for systems of skeletal quantitative traits: principal component
analysis of the canid skeleton / Chase K, Carrier DR, Adler FR, Jarvik T,
Ostrander EA, Lorentzen TD, Lark KG. // Proc Natl Acad Sci U S A.-2002.-1999.- P.9930-9935.
Exercise training enhanced SIRT1 longevity signaling replaces the IGF1
survival pathway to attenuate aging-induced rat heart apoptosis / Lai CH, Ho
TJ, Kuo WW, Day CH, Pai PY, Chung LC, Liao PH, Lin FH, Wu ET,
Huang CY // Age (Dordr).- 2014.- Oct.- 36(5).- P. 9706.
Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson
(2007). Robbins Basic Pathology (8th ed.). Philadelphia: Saunders. pp. 345
Is mitral valve prolapse due to cardiac entrapment in the chest cavity? ACT
view / Raggi P, Callister TQ, Lippolis NJ, Russo DJ.// Chest. 2000 .-Mar.-117(3).- P. 636-42.
Boyko AR, Quignon P, Li L, Schoenebeck JJ, Degenhardt JD,Lohmueller
KE, Zhao K, Brisbin A, Parker HG, vonHoldt BM, Cargill M, Auton A,
Reynolds A, Elkahloun AG, Castelhano M, Mosher DS, Sutter NB, Johnson
GS, Novembre J, Hubisz MJ, Siepel A, Wayne RK, Bustamante CD,
Ostrander EA. A simple genetic architecture underlies morphological
variation in dogs. PLoS Biol. 2010 Aug 10;8(8).
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919785/pdf/pbio.1000451.p
df
Ross J. Dilated cardiomyopathy: concepts derived from gene deficient and
transgenic animal models / Ross J. //. Circ J. - 2002 .-March. - 66 (3): P.
–24.
Many roads lead to a broken heart: the genetics of dilated cardiomyopathy /
Schönberger J, Seidman CE // American Journal of Human Genetics.-2001.
August 69 (2).- P. 249–60.
Echocardiographic evaluation in asymptomatic relatives of patients with
dilated cardiomyopathy reveals preclinical disease / Mahon NG, Murphy
RT, MacRae CA, Caforio AL, Elliott PM, McKenna WJ // Annals of
Internal Medicine.- 2005.- July.- 143 (2): P.108–15.
Downloads
Issue
Section
License
Relationship between right holders and users shall be governed by the terms of the license Creative Commons Attribution – non-commercial – Distribution On Same Conditions 4.0 international (CC BY-NC-SA 4.0):https://creativecommons.org/licenses/by-nc-sa/4.0/deed.uk
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).