Clinical course of fibrinous uveitis of streptococcal aetiology in young stock
Abstract
There are four stages in the clinical course of fibrinous uveitis of young stock which are caused by pathogenetic mechanisms of the leukocytic system involved in the pathological process through granulocytes, lymphocytes and monocytes. Granulocytes and lymphocytes (effector link) actively oppose the invasion of beta- hemolytic streptococcus at the first two stages, while monocytes (effector and regulatory links) act as regulators of intercellular links of tri-cooperative leukocytic system of the body.
The aim of the work was to: study the stages of fibrinous uveitis of streptococcal etiology of cattle and their pathogenetic mechanisms. Experiments were conducted on 65 head of cattle of a patient with fibrinous uveitis of streptococcal etiology. The diagnosis was based on ophthalmologic studies - examination, palpation of the organ of vision, ophthalmoscopy, the use of Purkinje - Sanson's images, as well as keratoscopy. Hematologic studies were performed. In connection with the forced slaughter of individual animals, a pathoanatomical examination of the organ of vision was performed. In the course of fibrinous uveitis of streptococcal etiology of young cattle, we distinguish four stages: 1) inflammatory hyperemia of the vasculature, 2) fibrinous exudation and sinechia, 3) glaucoma and cataracts, resorption of the lens and the sclily body, and 4) subatrophy of the eye and the phenophthalm. The course of the stage of the disease is due to its pathogenetic mechanisms, in which the important role played by the leukocyte system: during the first two stages granulocytes, lymphocytes and monocytes actively counteract the invasion of beta-hemolytic streptococcus; the role of granulocytes on this is exhausting. In the III-th stage of the disease, the main pathogenetic value is taken over by lymphocytes and monocytes (effector unit); monocytes are further considered as regulators of intercellular interactions of the whole three-cooperative leukocyte system of the animal organism (regulatory link). In the IV-th stage of the disease in connection with the elimination of infectious pathogens and autoimmune factor (lens), the inflammatory process stops, subatrophy of the eye occurs. fibrinous uveitis must necessarily take into account the stage of the lesion and its pathogenetic mechanisms.
Keywords: uveitis, leukocytic system, granulocytes, lymphocytes, monocytes
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