INFLUENCE ALLOGENIC MESENCHIMAL STEM CELLS ON METASTASIS PROCESS IN MICE C57Bl/6 WITH TRANSPLANTANT LEWIS LUNG CARCINOMA

Authors

  • L. V. Kladnytska
  • A. Y. Mazurkiewich
  • L. V. Harmanchchuk
  • S. V. Velichko
  • O. I. Djus
  • V. V. Kovpak
  • O. Y. Dasykevych

Abstract

Influence аllogeneic mesenchymal stem cells in the process of metastasis in mice C57BL/6 with transplant metastatic Lewis lung carcinoma were investigated. Experiments were performed on C57Bl/6 male mice three- week-old, weighing 20-22 g. The process of metastasis in animal control and experimental groups differed significantly. The effect of allogeneic MSCs on process metastasis enters the vascular stage rather certifying a higher number of metastases larger size. The total number of metastases measuring 1.0 - 3.0 mm in the animals of experimental group is 52.5%, while in the control of this indicator - 31.4%. Value of the total volume of metastases by exposure allogeneic MSCs significantly higher 41.52+7.9 * than animals in the control group - 17,94 + 6,59 (P <0.05). The use of MSCs in mice with Lewis lung transplant carcinoma has influence on the increase in the total volume of metastasis (ɳ2x = 0.26, p <0.05).

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Issue

No. 227 (2015): (англ)

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Article

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