Дослідження вакцини інактивованої проти інфекційного ринотрахеїту великої рогатої худоби за показниками якості

Authors

  • М. М. Гулянич
  • В. В. Недосєков

Abstract

RESEARCH OF INACTIVATED VACCINE AGAINST INFECTIOUS BOVINE RHINOTRACHEITIS FOR QUALITY CRITERIA

M. M. Hulyanych, V. V. Nedosekov

Abstract. Infectious bovine rhinotracheitis is widespread throughout the world and causes significant losses in cattle industry. Vaccine is the main preventive measure in the fight against this disease in many countries. The article contains research results of quality criteria of vaccine against infectious bovine rhinotracheitis that we have developed from a selected in Ukraine strain "ВM". Laboratory methods established match of experimental batches of vaccine to local and international requirements for inactivated vaccines for animals. Presented results of the studies of chemical-physical and immunological parameters of quality of the developed vaccine. It has been established that vaccination of rabbits causes more than four-fold antibodies increase in serum of test animals, which is up to 21 days after vaccination averaged 8,06 log2.

Keywords: vaccine, vaccine prevention, infectious bovine rhinotracheitis, quality, laboratory studies

References

References

OIE Terrestrial Manual (2016). Chapter 2.4.12. — Infectious bovine rhinotracheitis / infectious pustular vulvovaginitis. Retrieved from http://www.oie.int/international-standard-setting/terrestrial-manual/access-online/.

Ellsworth, M. A., Brown, M. J., & Fergen, B. J. (2003). Safety of a modified-live combination vaccine against respiratory and reproductive diseases in pregnant cows. Vet.Ther, 4(2), 120-127.

Pastoret, P., Thiry, E., & Vindevogel, H. (1982). Problems lies a la latence lors de vaccination contre le virus de la rhinotracheite infectieuse bovine (Bovid Herpesvirus). Develop. Biol. Standart. 52, 455-161.

Malakieiev, A. S. (2013). Vaktsyna inaktyvovana proty infektsiinoho rynotrakheitu velykoi rohatoi khudoby dlia vnutrishnoshkirnoho zastosuvannia [Inactivated vaccine against infectious rhinotracheitis of cattle for intradermal application] Extended abstract of candidate’s thesis. Kharkiv [in Ukraine].

Hulyanych, M. M., Nedosekov, V. V., & Kleimanov, I. S. (2015). Tekhnolohichni aspekty vyhotovlennia inaktyvovanykh vaktsyn proty infektsiinoho rynotrakheitu velykoi rohatoi khudoby [Тechnology aspects for production of inactivated vaccines against infectious bovine rhinotracheitis]. Naukovo-tekhnichnyi biuleten Naukovo-doslidnyi tsentr biobezpeky ta ekolohichnoho kontroliu resursiv APK. - Scientific and technical bulletin Research Center biosafety and environmental control resources AIC, 3, 3, 58-63 [in Ukraine].

Krasochko, P. A. (2009). Biotehnologicheskie osnovy konstruirovanija i ispol'zovanija immunobiologicheskih preparatov dlja molodnjaka krupnogo rogatogo skota [Biotechnological bases of design and use of immunobiological drugs for young cattle]. Doctor’s thesis. Shhelkovo [in Russian].

Hulyanych, M. M., Nedosekov, V. V., & Hodovskyi, O. V. (2016). Pidbir ad’iuvantu dlia konstruiuvannia inaktyvovanoi vaktsyny proty infektsiinoho rynotrakheitu velykoi rohatoi khudoby [Selection of an adjuvant for the construction of the inactivated vaccine against infectious rhinotracheitis of cattle]. Veterynarna biotekhnolohiia. - Veterinary Biotechnology, 29, 93-99 [in Ukraine].

Hulyanych, M., Nedosekov, V., & Sobko, Y. (2016). Determination of Cultural Conditions of Infectious Bovine Rhinotracheitis Virus Strain “BM”. Annals of Agrarian Science, Elsevier, 14, 3, 201-204. Retrieved from http://www.sciencedirect.com/science/journal/15121887.

Downloads

Published

2018-05-16

Issue

No. 265 (2017)

Section

Article

License

Relationship between right holders and users shall be governed by the terms of the license Creative Commons  Attribution – non-commercial – Distribution On Same Conditions 4.0 international (CC BY-NC-SA 4.0):https://creativecommons.org/licenses/by-nc-sa/4.0/deed.uk

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).