Вивчення зміни деяких факторів патогенності вакцинного штаму В. Anthracis UA-07 після його ліофілізації

Authors

  • U. Yanenko Institute of Veterinary Medicine of the NAAS, Kyiv, Ukraine
  • O. Tarasov Institute of Veterinary Medicine of the NAAS, Kyiv, Ukraine
  • N. Hudz Institute of Veterinary Medicine of the NAAS, Kyiv, Ukraine
  • S. Tereshchenko Institute of Veterinary Medicine of the NAAS, Kyiv, Ukraine

Abstract

A lot of scientific papers of the national and international literature devoted to characterization of the biological properties of anthrax. It is well-known fact that in natural conditions along with the typical strains, atypical forms of anthrax agent are found quite often. It is believed that reproduction of anthrax in the soil is accompanied by the irreversible loss of its pathogenic properties. But there is also a view that some of these atypical strains in certain experimental conditions are able to repair and even enhance its pathogenicity. We therefore decided to investigate the changes of anti-lysozyme activity and toxigenicity titer of B. anthracis UA-07 culture after lyophilization and passage through the culture media and laboratory animals. It was found that the lyophilized vaccine strain of the anthrax pathogen is capable repair anti-lysozyme activity and increase toxin titer.

Author Biographies

  • U. Yanenko, Institute of Veterinary Medicine of the NAAS, Kyiv, Ukraine
    PhD, Senior Researcher
  • O. Tarasov, Institute of Veterinary Medicine of the NAAS, Kyiv, Ukraine
    PhD, Senior Researcher
  • N. Hudz, Institute of Veterinary Medicine of the NAAS, Kyiv, Ukraine
    PhD

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No. 201 (2014): Частина 1 (укр)

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