Ефективність комплексного лікування собак за злоякісних новоутворень молочної залози
Abstract
EFFECTIVENESS OF COMPREHENSIVE DOGS TREATMENT AT MALIGNANCIES TUMORS OF BREAST
А.R. Mysak, V. V. Pritsak, Y. M.Lenyo
Annotation. The article presents the results of research of monitoring clinical status and survival of dogs with mammary gland neoplasia by applying different treatments. Dogs of the first group (n=29) were conducted only surgical removal of tumors (mastectomy), the second group of animals (n=21) - excision of tumors and adjuvant chemotherapy, in the third group (n=26) it was used a complex method of treatment with the inclusion of rehabilitation therapy. Therapeutic efficiency of these measures according to a search was established by the results of clinical state of the animals, and also by the indicators of overall survival, disease-free survival of animals and the median life expectancy. Monitoring for the dogs was performed for two years.
It was established that on condition of the combination of surgical removal of the tumor and chemotherapy under the scheme CVD (cyclophosphamide, vincristine, dexamethasone) for the treatment of female dogs with malignant breast tumors is possible to achieve not only the remission of the disease for period of 18 months, but also to improve the quality of animals life. Herewith, the execution of six courses of adjuvant chemotherapy under the scheme CVD in dogs is accompanied by an acceptable side effects, not exceeding the Degree II of hematologic, gastrointestinal, hepato- and nephrotoxicity (according to the scale National Cancer Institute NCI CTC). It has also set up that the application for mastectomy and adjuvant chemotherapy under the scheme of cyclophosphamide – vincristine - dexamethasone, compared to only conduct surgical removal of tumors, mortality of animals was lower by 9.4% in the first year as compared of conducting only surgical removal of tumors, mortality of animals was lower by 9.4% in the first year and 3.1% - within two years of observations. With the use of a comprehensive schemes of treatment with the inclusion of rehabilitation therapy it was observed reduction in mortality of animals, respectively, to 11 and 10.1%. The median life expectancy of dogs with breast neoplasia for carrying mastectomy was for 12.5 months, for adjuvant chemotherapy - 17, and for the complex treatment with rehabilitation therapy - 19.5 months.
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