Anthelmintic-salt mixtures – an effective means in prevention of helminthiases in sheep
DOI:
https://doi.org/10.31548/ujvs2020.04.001Keywords:
Keywords, anthelmintic-salt mixture, microelements, helminths, helminthiases, extent of infestation, infestation intensityAbstract
Abstract. Mixed parasitic infestations are quite common among sheep in all climatic and geographical areas all over the world and cause significant economic damage to the sheep industry, so the development of modern tools for the treatment and prevention of helminthiases in sheep has a priority meaning. The purpose of the work was studying the effectiveness of the developed anthelmintic-salt mixture enriched with microelements (Co, I, Zn, Mn, Mg and Cu) against sheep helminths and its effect on hematological parameters of animals. Experimental studies were performed under laboratory and industrial conditions. During the experiment, helminthovoscopic and larvoscopic studies were performed to determine the degree of animal infestations with helminthic pathogens, as well as hematological studies – to assess the effect of the developed drug on the body of sheep. The results of laboratory studies have shown that one animal consumed an average of 6.48 g of anthelmintic-salt mixture per day. It was found that in the sheep of the experimental group the extent of infestation by Marshallagia was 18.75 %, Nematodirus – 6.25 %, other gastrointestinal Strongyloides – 43.75 %, Moniezia – 12.5 %, Fasciola – 37.5 %, Dictyocaulus – 25.0 %, while in the sheep of the control group, these figures were much higher and were 100.0 %, 87.5 %, 50.0 %, 50.0 %, 37.5 %, 62.5 %, and 50.0 %, respectively. The results of hematological studies showed that long-term feeding of anthelmintic-salt mixture enriched with trace elements does not have a negative effect on the body of sheep. When conducting studies directly under sheep farm conditions, in sheep fed for 8 months anthelmintic-salt mixture enriched with trace elements, the extent of helminth infestation was 28.6 %, while among sheep in the control group, this figure was 70.0 %. Therefore, the results of studies indicate the feasibility of using anthelmintic-salt mixture enriched with trace elements for the treatment and prevention of helminthiasis in sheep.
Keywords: anthelmintic-salt mixture, microelements, helminths, helminthiases, extent of infestation, infestation intensity
References
Aripov, A. O., Tuhtaboev, M. A., Haziev, S. A., & Umirzakov, Z. A. (2020). Perspektivy I problemy razvedeniya ovcevodstva innovacionnye tekhnologii i tekhnicheskie sredstva dlya uluchsheniya estestvennyh pastbishch [Prospects and problems of sheep breeding, innovative technologies and technical means for improving natural pastures]. Innovacion tekhnologiyalar, (Special issue), 6-11.
Bashtar, A. R., Hassanein, M., Abdel-Ghaffar, F., Al-Rasheid, K., Hassan, S., Mehlhorn, H., ... & Al-Ghamdi, A. (2011). Studies on monieziasis of sheep I. Prevalence and antihelminthic effects of some plant extracts, a light and electron microscopic study. Parasitology Research, 108(1), 177-186.
Biswal, D. (2016). Molecular methods for diagnosisof zoonotic helminths: can they be made accessible to the common man? Advancements in Genetic Engineering, 5, 149. doi:10.4172/2169-0111.1000149
Borji, H., Raji, A. R. & Naghibi, A. (2011). The comparative morphology of Marshallagia marshalli and Ostertagia occidentalis (Nematoda: Strongylida, Trichostrongylidae) by scanning electron microscopy. Parasitology Research, 108, 1391-1395. doi: 10.1007/s00436-010-2186-2.
Coulson, G., Cripps, J. K., Garnick, S., Bristow, V., & Beveridge, I. (2018). Parasite insight: assessing fitness costs, infection risks and foraging benefits relating to gastrointestinal nematodes in wild mammalian herbivores. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1751), 20170197. doi: 10.1098/rstb.2017.0197
Dallas, J. F., Irvine, R. J., Halvorsen, O., & Albon, S. D. (2000). Identification by polymerase chain reaction (PCR) of Marshallagia marshalli and Ostertagia gruehneri from Svalbard reindeer. International Journal for Parasitology, 30(7), 863-866.
Dimitrijević, B., Borozan, S., Katić-Radivojević, S., & Stojanović, S. (2012). Effects of infection intensity with Strongyloides papillosus and albendazole treatment on development of oxidative/nitrosative stress in sheep. Veterinary parasitology, 186(3-4), 364-375. doi: 10.1016/j.vetpar.2011.11.017
Karlsson, L. J. E., & Greeff, J. C. (2012). Genetic aspects of sheep parasitic diseases. Veterinary parasitology, 189(1), 104-112. doi: 10.1016/j.vetpar.2012.03.039.
Levecke, B., Rinaldi, L., Charlier, J., Maurelli, M. P., Bosco, A., Vercuysse, J. & Cringoli, G. (2012). The bias, accuracy and precision of faecal egg count reduction test results in catile using Mc- Master, Cornell–Wisconsin and FLOTAC egg counting method. Veterinary Parasitology, 188, 194-199. doi: 10.1016/j.vetpar.2012.03.017.
Mair, G. R., Halton, D. W., & Maule, A. G. (2020). The neuromuscular system of the sheep tapeworm Moniezia expansa. Invertebrate Neuroscience, 20(4), 1-10. doi: 10.1007/s10158-020-00246-2
Melville, L., Redman, E., Morrison, A. A., Chen, P. C. R., Avramenko, R., Mitchell, S., ... & Gilleard, J. S. (2020). Large scale screening for benzimidazole resistance mutations in Nematodirus batius, using both pyrosequence genotyping and deep amplicon sequencing, indicates the early emergence of resistance on UK sheep farms. International Journal for Parasitology: Drugs and Drug Resistance, 12, 68-76. doi: 10.1016/j.ijpddr.2020.03.001
Moradpour, N., Borji, H., Razmi, G., Maleki, M., & Kazemi, H. (2013). Pathophysiology of Marshallagia marshalli in experimentally infected lambs. Parasitology, 140(14), 1762-1767. doi: 10.1017/S0031182013001042
Morrison, A. A., Mitchell, S., Mearns, R., Richards,I., Matihews, J. B., & Bartley, D. J. (2014). Phenotypic and genotypic analysis of benzimidazole resistance in the ovine parasite Nematodirus batius. Veterinary research, 45(1), 1-10. doi: 10.1186/s13567-014-0116-5
Obanda, V., Maingi, N., Muchemi, G., Ng’ang’a, C. J., Angelone, S., & Archie, E. A. (2019). Infection dynamics of gastrointestinal helminths in sympatric non-human primates, livestock and wild ruminants in Kenya. PloS one, 14(6), e0217929. doi: 10.1371/journal.pone.0217929
Oripov, A. O., Yuldashev, N. E., & Dzhabborov, Sh. A. (2007). Patent UzIAP03349. Means for chemoprophylaxis of helminths in karakul farms. Patent Office Res. Uzbekistan, Tashkent.
Oripov, A. O., Yuldashev, N. E., & Dzhabborov, Sh. A. (2007). Patent UzIAP03350. Means for chemoprophylaxis of small catile helminths. Patent Office Res. Uzbekistan, Tashkent.
Oripov, A. O., Yuldashev, N. E., & Dzhabborov, Sh. A. (2007). Patent UzIAP03351. Means for chemoprophylaxis of sheep and goat helminths. Patent Office Res. Uzbekistan, Tashkent.
Pyziel, A. M., Laskowski, Z., & Höglund, J. (2015). Development of a multiplex PCR for identification of Dictyocaulus lungworms in domestic and wild ruminants. Parasitology research, 114(10), 3923-3926. doi: 10.1007/s00436-015-4657-y
Robinson, M. W., & Dalton, J. P. (2009). Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 364(1530), 2763-2776. doi: 10.1098/rstb.2009.0089
Sevimli, F. K., Kozan, E., & Dogan, N. (2011). Efficacy of eprinomectin pour-on treatment in sheep naturally infected with Dictyocaulus filaria and Cystocaulus ocreatus. Journal of helminthology, 85(4), 472. doi: 10.1017/S0022149X10000854
Taylor, M. A. (2012). Emerging parasitic diseases of sheep. Veterinary parasitology, 189(1), 2-7.
Sayers, G., & Sweeney, T. (2005). Gastrointestinal nematode infection in sheep – a review of the alternatives to anthelmintics in parasite control. Animal Health Research Reviews, 6(2), 159. doi:10.1079/AHR2005108
Vlassoff, A., Leathwick, D. M., & Heath, A. C. G. (2001). The epidemiology of nematode infections of sheep. New Zealand Veterinary Journal, 49(6), 213-221.
Downloads
Published
Issue
Section
License
Relationship between right holders and users shall be governed by the terms of the license Creative Commons Attribution – non-commercial – Distribution On Same Conditions 4.0 international (CC BY-NC-SA 4.0):https://creativecommons.org/licenses/by-nc-sa/4.0/deed.uk
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).