Pathomorphological changes in cats with chlamidiosis

Автор(и)

  • N. B. Kolych National University of Life and Environmental Sciences of Ukraine, Kyiv, Ukraine ,
  • N. Hudz Institute of Veterinary Medicine NAAS

Ключові слова:

coronavirus infection, dogs, histological changes, hemorrhages, serofibrinous jejunoileitis, serohemorrhagic lymphadenitis, hyperplasia, lymphoid nodules.

Анотація

In recent years, there is a tendency to increase the incidence of the disease in dogs with signs of diarrhea, not only in Ukraine, but also in Europe. In general, diseases with the manifestation of such specific clinical sign as diarrhea can be caused by viruses, bacteria and helminths. In general pathology of dogs, enterovirus infections of puppies occupy a leading place. The practice of specific prophylaxis suggests that in the etiological aspect diseases emerging with this symptom can be caused not only by parvo-, but also corona- and rotavirus enteritis. These diseases are extremely dangerous for puppies and miniature dogs, due to rapid dehydration, and as a result, death.

The article presents the results of a study on histological changes in organs and tissues of dogs with coronavirus infection. A histological study of pathological material sampled from 6 dogs of various breeds and sex, aged from 2 to 6 months, died from diarrheal syndrome was carried out. The presence of the coronavirus was confirmed in fecal samples by polymerase chain reaction.

The most expressed injuries and typical changes in all dead dogs we recorded in the small intestine, namely in the jejunum and ileum, regional lymph nodes, and also in the spleen.

Morphological manifestations of coronavirus infection in dogs at macroscopic level are the following signs: the presence of exudative inflammation in the small intestine in form of serous-fibrinous jejunoileitis, hyperplasia and serohemorrhagic lymphadenitis of the mesenteric lymph nodes, multiple foci of hemorrhage in the parenchyma of the spleen and serous membrane of the small intestine, passive venous hyperemia of the liver and kidneys, dilatation of the right ventricle of the heart, pulmonary edema, cachexia and dehydration of the body.

At the microscopic level we registered the following: serofibrinous jejunoileitis, hyperplasia of the lymphoid nodules of the spleen and lymph nodes, hemorrhagic infarctions in the spleen, hyperplasia of individual and aggregated lymphoid nodules of the mucous membrane in the small intestine, degenerative processes in the parenchyma of the liver and kidneys.

 

Посилання

Ann S.Y., Kim H.T., Kim, D. (2014). M gene analysis of canine coronavirus strains detected in Korea. J Vet Sci. 15, 495-502.

https://doi.org/10.4142/jvs.2014.15.4.495

Decaro, N., Mari, V., von Reitzenstein, M. (2012). A pantropic canine coronavirus genetically related to the prototype isolate CB/05. Vet Microbiol. 159 (1-2), 239-244.

https://doi.org/10.1016/j.vetmic.2012.03.039

Gizzi, A.B.R., Oliveira, S.T., Leutenegger, C.M. et al. (2014). Presence of infectious agents and co-infections in diarrheic dogs determined with a real-time polymerase chain reaction-based panel. BMC Veterinary research, 6, 81-90.

https://doi.org/10.1186/1746-6148-10-23

Goralskij, L.P., Homych, V.T., Kononskij, O.I. (2011). Osnovy histologichnoyi tehniky i morfofunkcionalni metody doslidjen u normi ta pry patologiyi [Foundations of histological engineering and morphofunctional methods of research in norm and pathology]. Jytomir, Ukrainian: Polissya (in Ukrainian).

Godsall S.A. Epidemiology of canine parvovirus and coronavirus in dogs presented with severe diarrhoea to PDSA / Godsall SA, Clegg SR, Stavisky JH // Pet Aid hospitals. Vet Rec. - 2010. - 167. - P. 196-201, doi: 10.1136/vr.c3095.

https://doi.org/10.1136/vr.c3095

Graham R. L. Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform / R. L. Graham, D. J. Deming, M. E. Deming, B. L. Yount, R. S. Baric // Communications Biology. - 2018. - V. 1. - Article number: 179. Режим доступу: https://www.nature.com/articles/s42003-018-0175-7

https://doi.org/10.1038/s42003-018-0175-7

Karesh W. B. Ecology of zoonoses: natural and unnatural histories / W. B. Karesh, A. Dobson, J. O. Lloyd-Smith et al. // Lancet, 2012. - V. 380. - P. 1936-1945.

https://doi.org/10.1016/S0140-6736(12)61678-X

Pratelli A. The Evolutionary Processes of Canine Coronaviruses / A. Pratelli // Advances in Virology. - Vol. 2011. - Article ID 562831, 10pages.doi.org/10.1155/2011/562831. Режим доступу: https://www.hindawi.com/journals/av/2011/562831/

https://doi.org/10.1155/2011/562831

Stavisky J. Cross sectional and longitudinal surveys of canine enteric coronavirus infection in kennelled dogs: a molecular marker for biosecurity / J. 125 Stavisky, G. Pinchbeck, RM. Gaskell et al. // Infect Genet Evol. - 2012. - 12. - P. 1419-1426.

https://doi.org/10.1016/j.meegid.2012.04.010

Su S. Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses / S. Su, G. Wong, W. Shi, J. Liu, A. C.K. Lai et all. // Trends in microbiology. - 2016. - 24 (6). - P. 490-502.

https://doi.org/10.1016/j.tim.2016.03.003

Takano T. Prevalence of canine coronavirus (CCoV) in dog in Japan: detection of CCoV RNA and retrospective serological analysis / T. Takano, S. Yamashita, M. Murata-Ohkubo, K. Satoh, T. Doki and T. Hohdatsu //J Vet Med Sci. - 2016. - 78(2). - P. 341-345.

https://doi.org/10.1292/jvms.15-0347

Wang, X., Li, C., Guo, D. (2016). Co-Circulation of Canine Coronavirus I and IIa/b with High Prevalence and Genetic Diversity in Heilongjiang Province, Northeast China. Available at: http://journals.plos.org/plosone/ articleid=10.1371/journal.pone.0146975 Jeoung,

https://doi.org/10.1371/journal.pone.0146975

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2021-09-23

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