Definition of ointments with the optimal ointment base proportion for dermatomycoses treatment

Authors

  • Y. V. Palytsja National University of Life and Environmental Sciences of Ukraine image/svg+xml
  • M. F. Pan’ko National University of Life and Environmental Sciences of Ukraine image/svg+xml
  • V. D. Ishchenko National University of Life and Environmental Sciences of Ukraine image/svg+xml

Abstract

It has been studied the importance and optimal ratio of the ointment bases with salicylic acid, resorcinol and boric acid for the treatment of dermatomycosis of dogs affected by Microsporum, Trichophyton and Candida albicans. The formulations with the same concentrations of basic active ingredients and different amounts of the ointment bases had the distinct efficiency against various dermatomycosis pathogens.

Nonexudative dermatomycosis (caused by Trichophyton and Microsporum) can be effectively treated by the ointment with 1:9 and 6:4 Vaseline/Lanoline ratios. With such salicylic acid, resorcinol and boric acid ointments administration, the disease and assotiated symptoms have been resolved in 12 days of therapy.

At the exudative dermatomycosis (caused by Candida) treatment, the recommended ratios of ointment bases are those that involve more Lanoline than Vaseline. Ointment formulation № 2 with 6:4 Vaseline/Lanoline ratio administered has been found to achieve comparable therapeutic effect in 6 days and mycological cure rates in 12 days of therapy.

Keywords: ointment, ointment bases, dermatomycosis, salicylic acid, resorcinol, boric acid

References

Gretskiy, V. M., Homenok V. S. (2000). Rukovodstvo k prakticheskim zanyatiyam po tehnologii lekarstvennyih form [Guidance to practical employments on technology of medicinal forms]. Moskow:, Meditsina, 304.

Derzhavna Farmakopeya Ukrayini (2001). [StatePharmacopoeiaofUkraine]. Harkiv : RIREG, 544.

Medvedev, K. S. (1999). Bolezni kozhi sobak i koshek [Diseases of skin of dogs and cats]. Kiev: Vima,152.

Tihonov, O. I., Yarnih T. G. (2007). Aptechna tehnologiya likiv [pharm technology of medicinal preparations]. Vinnitsya: Nova kniga, 640.

Pinter Lj., Štritof Z. (2004). A retrospective study of Trichophyton mentagrophytes infection in dogs. Vet. Arhiv, 74(4), 251–260.

Nenoff P., Krüger C., Ginter-Hanselmayer G., Tietz H.J. (2014).Mycology – an update. Part 1: Dermatomycoses: causative agents, epidemiology and pathogenesis,J. Dtsch. Dermatol. Ges, 12(3), 188–209.

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Published

2018-07-23

Issue

No. 273 (2017)

Section

Article

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