Protein and nonprotein nitrogenous components metabolism in chickens at chronic poisoning with mospilan and an akhtara
Abstract
The study of chronic toxicity of insecticidal mospilan and akhtara preparations for laying hens has been conducted.
It was found that when feeding laying hens with a feed containing mospilan in the doses of 65 mg/kg-bw and 32.5 mg/kg-bw and preparation akhtara in the doses of 360 mg/kg-bw and 180 mg/kg-bw (1/10 DL50 and 1/20 DL50 for mice) for 30 days, they showed general toxic effect without visible signs of poisoning and death of poultry.
Biochemical studies of blood plasma showed pronounced decrease in the content of total protein and its major fractions – albumins and globulins, which indicates the development of hypoproteinemia and inhibition of protein-synthesizing function of the liver.
The content of uric acid and creatinine in the blood plasma of the poultry of all experimental groups was higher than this index in control one during all time of the study.
It was found that in 10 days after the full stop of feeding laying hens with the feed containing mospilan and akhtara preparations, the most of the tested indices of the poultry experimental groups were not recovered compared to the level of control group, which indicates the presence of cumulative properties of acetamiprid and thiamethoxam, which are the active substances of mospilan and akhtara preparations respectively.
Keywords: neonicotinoids, mospilan, akhtara, laying hens, chronic toxicity
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