Toxigence of anthrax vaccine strains
DOI:
https://doi.org/10.31548/ujvs2020.03.009Abstract
Abstract. The article presents the results of the study of strains of anthrax and anthrax bacilli on the formation of toxins. We found that anthrax vaccine strains actively produce exotoxins to the culture fluid. The amount of specific protein is different under the same incubation conditions and depends on the individual characteristics of the population of microorganisms, because of this, different titers of the toxin are registered.
Strain B. anthracis K-79 Z (vaccine) with the same number of planting microbial cells and growing on the same nutrient medium and temperature produces two orders of magnitude more exotoxin than strains of B. anthracis Tsenkovsky II IVM 92 Z (virulent), B. anthracis Stern 34F2, (vaccine), B. anthracis 55 (vaccine), B. anthracis SB (vaccine), B. anthracis Tsenkovsky I (vaccine, аpathogenic). The amount of exotoxin may change as the pH of the medium changes. The activity of exotoxin production when the pH changes depends on the characteristics of the anthrax strain.
Key words: anthrax, exotoxin, exotoxin production
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