Надіслати цю статтю Microscopic changes in the internal organs of white mice during experimental iron (iv) clathrochelate toxicosis
Анотація
Iron (IV) clatrochelate based on a macrocyclic ligand of the hexahydrazide type is a unique compound that contains iron in a rare high valence IV. Preclinical and clinical studies of this complex, which were started for the first time in Ukraine, have an important theoretical and practical consequence as this complex can be recommended as an active substance in iron-containing drugs with antianemic action.
In conducting preclinical studies of new drugs, pathomorphological studies are important because they are a necessary step in studying the biological response of animals to the action of test substances. It was found that some pathological changes develop in the body of white mice under conditions of experimental acute and chronic intoxication of iron (IV) clathrochelate. They correlated with the dose of the test compound. During chronic intoxication the microscopic changes of liver and kidney of white mice treated with iron (IV) clatrofelate at a dose of 1/10 DL50 were similar to the microscopic changes in the liver and kidney of mice treated with the experimental drug at a dose of 1/5 DL50. However, the severity of these changes was lower, reflecting a lower degree of organ damage. In the myocardium of mice treated with iron (IV) clatrochelate at a dose of 1/5 DL50 on the 10th day, as in acute poisoning of iron (IV) clatrochelate, only edema was recorded. The prospects for further research are the study of microscopic changes in the organs of laboratory animals of other species in experimental toxicosis of iron (IV) clathrochelate.
Keyword: iron, pathomorphological studies, liver, kidneys, heart, toxicity.
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Antipov, A.A., & Zharov, A.V. (2013). Gistologicheskie i morfometricheskie izmenenija pecheni, pochek, selezenki i limfaticheskih uzlov u porosjat pri alimentarnoj zhelezodeficitnoj anemii [Histological and morphometric changes in the liver, kidney, spleen and lymph nodes of piglets with nutritional iron deficiency anemia]. Rossijskij veterinarnyj zhurnal [Russian veterinary journal], 1, 19–21. Retrieved from https://cyberleninka.ru/article/n/gistologicheskie-i-morfometricheskie-izmeneniya-pecheni-pochek-selezenki-i-limfaticheskih-uzlov-porosyat-pri-alimentarnoy [in Russian].
Chetverikova, T.D., Krasnikova, I.M., Medvedeva, S.A., Aleksandrova, G.P., Grishchenko, L.A., & Kuklina, L.V. (2006). Modelirovanie I korekchija alimentarnoj anemii [Modeling and correction of iron deficiency anemia]. Bulletenˊ VSNC CO RAMN [Bulletin of VANC CU RAMN], 5, 246–251. [in Russian].
Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2018). Vyznachennja parametriv gostroi toksychnosti ferumu (IV) na bilyh myshah [Determination of the accumulative toxicity parameters of iron (IV) on white mice]. Ukrainian Journal of Ecology, 8 (2), 308–312. DOI: 10.15421/2018_343 [in Ukrainian].
Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I.O., & Plutenko, M. O. (2019). Khronichna toksychnist klatrokhelatu Ferumu (IV) dlia bilykh shchuriv [Chronic toxicity of the Iron (IV) clathrochelate complexes for white rats]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 21(95), 15–21. DOI: 10.32718/nvlvet9503 [in Ukrainian].
Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Cumulative properties of Iron(IV) clathrochelate in rats [Kumuliatyvni vlastvosti klatrokhelatu Ferumu (IV) dlia bilykh shchuriv]. Visnyk PDAA [Messenger PDAA], 2, 238–246. DOI: 10.31210/visnyk2019.02.32 [in Ukrainian].
Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Acute toxicity of the iron clathrochelate complexes. Regulatory Mechanisms in Biosystems, 10(3), 276–279. DOI: 10.15421/021942
Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2019). Influence of iron (IV) clathrochelate complex on quail blood parameters and weight characteristics. Ukrainian Journal of Ecology, 9 (3), 126–131. DOI: 10.15421/2019_719
Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I. O., & Plutenko, M. O. (2020). Doslidzhennia podrazniuvalnoi dii ta alerhennykh vlastyvostei klatrokhelatu Ferumu(IV) [Investigations of the irritant effect and allergenic properties of Fermat's clatrochelate (IV)]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(97), 130–135. DOI: 10.32718/nvlvet9721 [in Ukrainian].
Dukhnitsky, V. B., Kalachniuk L. H., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2020). Iron(IV) hexahydrazide clathrochelate complexes: the chronic toxicity study. Ukrainian Journal of Ecology, 9 (3), 18–23. DOI: 10.15421/2020_3
Goralsky, L.P., Khomich, V.T., & Kononsky, O.I. (2005). Osnovy histolohichnoi tekhniky i morfofunktsionalni metody doslidzhennia u normi ta pry patolohii [Fundamentals of histological technique and morphofunctional research methods in normal and pathology]. Zhytomyr. Polissya [in Ukrainian].
Hohenberger, J., Ray, K., & Meyer, K. (2012). The biology and chemistry of high-valent iron-oxo and iron-nitrido complexes. Nature communications, 3, 720. DOI: 10.1038/ncomms1718
Krahe, O., Bill, E., & Neese, F. (2014). Decay of iron(V) nitride complexes by a N-N bond-coupling reaction in solution: a combined spectroscopic and theoretical analysis. Angewandte Chemie (International ed. in English), 53(33), 8727–8731. DOI:10.1002/anie.201403402
Kloß, S. D., Haffner, A., Manuel, P., Goto, M., Shimakawa, Y., & Attfield, J. P. (2021). Preparation of iron(IV) nitridoferrate Ca4FeN4 through azide-mediated oxidation under high-pressure conditions. Nature communications, 12(1), 571. DOI: 10.1038/s41467-020-20881
Kocjumbas, I. Ja. (2006). Doklinichni doslidzhennja vet-erynarnyh likars'kyh zasobiv. L'viv. Triada pljus [in Ukrainian].
Luhovskyi, S. P., Dmytrukha, N. M., Didenko, M. M., Bakalo, L. V., Lahutina, O. S., & Melnyk, N. A. (2019). Morfofunktsionalni zminy vnutrishnikh orhaniv shchuriv za tryvaloho vvedennia v cherevnu porozhnynu nanochastynok oksydu zaliza (Fe2O3) [Morphofunctional changes in the internal organs of rats with prolonged introduction into the abdominal cavity of nanoparticles of iron oxide (Fe2O3)]. Ukrainskyi zhurnal z problem medytsyny [Ukrainian Journal of Medicine], 15 (3), 228–239. DOI: 10.33573/ujoh2019.03.228
MachalováŠišková, K., Jančula, D., Drahoš, B., Machala, L., Babica, P., Alonso, P. G., Trávníček, Z., Tuček, J., Maršálek, B., Sharma, V. K., & Zbořil, R. (2016). High-valent iron (Fe(VI), Fe(V), and Fe(IV)) species in water: characterization and oxidative transformation of estrogenic hormones. Physical chemistry chemical physics, 18(28), 18802–18810. DOI: 10.1039/c6cp02216b
Nam, W., Lee, Y. M., & Fukuzumi, S. (2014). Tuning reactivity and mechanism in oxidation reactions by mononuclear nonheme iron(IV)-oxo complexes. Accounts of chemical research, 47(4), 1146–1154. DOI: 10.1021/ar400258p
Prakash, O., Chábera, P., Rosemann, N. W., Huang, P., Häggström, L., Ericsson, T., Strand, D., Persson, P., Bendix, J., Lomoth, R., & Wärnmark, K. (2020). A Stable Homoleptic Organometallic Iron(IV) Complex. Chemistry (Weinheim an der Bergstrasse, Germany), 26(56), 12728–12732. DOI: 10.1002/chem.202002158
Shylin, S. I., , Pavliuk, M. V., , D'Amario, L., , Fritsky, I. O., & Berggren, G., (2019). Photoinduced hole transfer from tris(bipyridine)ruthenium dye to a high-valent iron-based water oxidation catalyst. Faraday discussions, 215(0), 162–174. DOI: 10.1039/c8fd00167g
Tomyn, S., Shylin, S. I., Bykov, D., Ksenofontov, V., Gumienna-Kontecka, E., Bon, V. & Fritsky, I.O. (2017). Indefinitely stable iron (IV) cage complexes formed in water by air oxidation. Nature Communications, 8, 1−8. DOI: 10.1038/ncomms14099
Zon, G.A., Skrypka, M.B., & Ivanivska, L.B. (2009). Pathological autopsy of animals [Pathological autopsy of animals]. Donetsk. PP Glazunov R.O. [in Ukrainian].
Weiss, R., Bulach, V., Gold, A., Terner, J., & Trautwein, A. X. (2001). Valence-tautomerism in high-valent iron and manganese porphyrins. Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry, 6(8), 831–845. DOI: 10.1007/s007750100277
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