Changes in the synovial fluid of the knee joint of the rabbit because of experimental osteoarthritis

Authors

  • Y. V. Demiantseva National University of Life and Environmental Sciences of Ukraine image/svg+xml
  • M. O. Maluyk National University of Life and Environmental Sciences of Ukraine image/svg+xml

Abstract

Osteoarthritis (OA) combines a group of diseases of different etiologies, but with similar biological, morphological and clinical outcomes, in which not only the articular cartilage, but also the entire joint (and synovial fluid) are involved in the pathological process. Synovial fluid (SF) subtly reacts to the smallest disorders of the joint function, altering its composition. This allows us to detect early changes in the joint and start treatment on time, which is especially important in osteoarthritis.

For experimental osteoarthritis caused by the double administration of retinol acetate at day 7 there is an active inflammatory reaction characterized by increased volume of synovial fluid and the presence of a large number of cells (eosinophils, lymphocytes, macrophages, synovial cells, neutrophils). At day 14 aseptic synovitis passes into classical arthritis-arthrosis. Under these conditions the inflammatory process is present, but not so active. The number of cells is less than 7 days of the experiment, while the macrophages are characterized by a foamy cytoplasm. At day 28, signs of osteoarthritis were observed, with cellularity close to normal, the number of macrophages increased, and neutrophils and lymphocytes were reduced.

Keywords: rabbit, knee joint, retinol acetate, synovial fluid, synovial cells, macrophages, lymphocytes, neutrophils, osteoarthrosis

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Published

2018-07-23

Issue

No. 273 (2017)

Section

Article

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