COMPARATIVE STUDY OF MOSPILAN AND AKHTARA CHRONIC TOXICITY FOR WHITE MICE

Authors

  • G. Bazaka National University of Bioresources and Nature Management Of Ukraine , National University of Bioresources and Nature Management Of Ukraine
  • Volodimyr Dukhnitskyi National University of Bioresources and Nature Management Of Ukraine , National University of Bioresources and Nature Management Of Ukraine
  • V. Ishchenko National University of Bioresources and Nature Management Of Ukraine , National University of Bioresources and Nature Management Of Ukraine

Abstract

The results of studies on determination of chronic toxicity of
Mospilan and Akhtara insecticides from the neonicotinoids group, whose
active substances are acetamiprid and thiamethoxam, respectively are
represented in the paper. The manifestation of chronic toxicity was assessed
by changes in the indices of the clinical state, morphological and biochemical
indices of blood, pathomorphological studies. Clinical manifestations of
poisoning and animals death were not observed. Investigations of the blood
morphological composition at chronic poisoning with Mospilane after its
introduction in 1/10 DL50 dose, thrombocytosis and neutrophilic leukocytosis
including right shift were registered, as well as lymphocytopenia.
Thrombocytosis and leukocytosis also developed at poisoning with Akhtara in
the appropriate dose, but without changes of the leukogram.
In blood serum of animals after Mospilan and Akhtara poisoning the
content of the total protein increased due to the globulin fraction. In the serum
of white mice poisoned by Mospilan, the urea content was reduced by 43.6%
against the constant creatinine content and a significant increase of the activity
of ALAT, AspAT, and a simultaneous increase of GTP activity, which indicated
significant dysfunction of the synthetic liver function with hepatocytolysis in
animals.
Increased GTP activity without changes in ALT activity indicated
dysfunction in the hepatobiliary system at chronic poisoning with Akhtara.
A significant increase of AspAT activity under the influence of Mospilan
and Akhtara confirms the effect of both pesticides on nicotine-sensitive
receptors in mice. The more significant influence of Mospilan as compared to
Akhtara on the blood system and liver is associated with a higher degree of
toxicity of the active substance.
Keywords: neonicotinoids, Mospilan, Akhtara, acetamiprid,
thiamethoxam, toxicity, laboratory mice, blood, liver, enzyme activity

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Published

2019-03-05

Issue

No. 285 (2018)

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Article

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