LEVEL OF OXIDATIVE DAMAGE OF PROTEINS AND INTENSITY OF LIPID PEROXIDATION PROCESSES IN THE ORGANISM OF COMMON CARPS AFFECTED BY AEROMONOSIS, AND IN THE TREATMENT OF «FLYUMEK»
Abstract
Currently, not only the search for effective agents for the treatment of bacterial diseases in fish, but also a comprehensive study of the influence of these agents on the body is relevant. The purpose of our work was to find out the level of oxidative damage of proteins and the intensity of processes
lipid peroxidation in the organism of carp affected by aeromonosis and in the treatment of the drug "Flyumek" and its complex with milk thistle seeds. Experiments were carried out on patients with aeromonosis of two-yearold carps, which, by analogy, were divided into three experimental groups, the control group was clinically healthy fish, with 4 individuals in each. The first group, clinically healthy fish, received 3% starch suspension, the second group received only 3% starch suspension, the third group, the experimental group, which received an antibacterial drug "Flumek" at the rate of 10 mg/kg of fish consisting of 3% starch suspension for 7 days, in the fourth experimental group, besides the similar dose of the antibacterial drug, 5% of the ground Milk thistle seeds was given spotted (Silybum marianum). The results of the research showed that aeromonosis disease of carps by leads to an increase in the intensity of the processes of lipid peroxidation in blood plasma of fish and aldehyde and ketone derivatives of oxidationmodified proteins, as evidenced by a significantly higher level of their indicators in the sick fish compared to healthy. The introduction of the drug "Flumek" to carp which afected of aeromonosis, separately and in combination with the seeds of Milk thistle caused a possible decrease in the content of aldehyde and ketone derivatives of oxidative modification of proteins, lipids hydroperoxides and TBA-active products. Keywords: сarp, aeromonosis, «Flyumek», flumequin, Milk thistle, oxidatively modified proteins, lipid peroxidation
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