Дослідження вакцини інактивованої проти інфекційного ринотрахеїту великої рогатої худоби за показниками якості



М. М. Гулянич, В. В. Недосєков

Анотація


RESEARCH OF INACTIVATED VACCINE AGAINST INFECTIOUS BOVINE RHINOTRACHEITIS FOR QUALITY CRITERIA

M. M. Hulyanych, V. V. Nedosekov

Abstract. Infectious bovine rhinotracheitis is widespread throughout the world and causes significant losses in cattle industry. Vaccine is the main preventive measure in the fight against this disease in many countries. The article contains research results of quality criteria of vaccine against infectious bovine rhinotracheitis that we have developed from a selected in Ukraine strain "ВM". Laboratory methods established match of experimental batches of vaccine to local and international requirements for inactivated vaccines for animals. Presented results of the studies of chemical-physical and immunological parameters of quality of the developed vaccine. It has been established that vaccination of rabbits causes more than four-fold antibodies increase in serum of test animals, which is up to 21 days after vaccination averaged 8,06 log2.

Keywords: vaccine, vaccine prevention, infectious bovine rhinotracheitis, quality, laboratory studies

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References

OIE Terrestrial Manual (2016). Chapter 2.4.12. — Infectious bovine rhinotracheitis / infectious pustular vulvovaginitis. Retrieved from http://www.oie.int/international-standard-setting/terrestrial-manual/access-online/.

Ellsworth, M. A., Brown, M. J., & Fergen, B. J. (2003). Safety of a modified-live combination vaccine against respiratory and reproductive diseases in pregnant cows. Vet.Ther, 4(2), 120-127.

Pastoret, P., Thiry, E., & Vindevogel, H. (1982). Problems lies a la latence lors de vaccination contre le virus de la rhinotracheite infectieuse bovine (Bovid Herpesvirus). Develop. Biol. Standart. 52, 455-161.

Malakieiev, A. S. (2013). Vaktsyna inaktyvovana proty infektsiinoho rynotrakheitu velykoi rohatoi khudoby dlia vnutrishnoshkirnoho zastosuvannia [Inactivated vaccine against infectious rhinotracheitis of cattle for intradermal application] Extended abstract of candidate’s thesis. Kharkiv [in Ukraine].

Hulyanych, M. M., Nedosekov, V. V., & Kleimanov, I. S. (2015). Tekhnolohichni aspekty vyhotovlennia inaktyvovanykh vaktsyn proty infektsiinoho rynotrakheitu velykoi rohatoi khudoby [Тechnology aspects for production of inactivated vaccines against infectious bovine rhinotracheitis]. Naukovo-tekhnichnyi biuleten Naukovo-doslidnyi tsentr biobezpeky ta ekolohichnoho kontroliu resursiv APK. - Scientific and technical bulletin Research Center biosafety and environmental control resources AIC, 3, 3, 58-63 [in Ukraine].

Krasochko, P. A. (2009). Biotehnologicheskie osnovy konstruirovanija i ispol'zovanija immunobiologicheskih preparatov dlja molodnjaka krupnogo rogatogo skota [Biotechnological bases of design and use of immunobiological drugs for young cattle]. Doctor’s thesis. Shhelkovo [in Russian].

Hulyanych, M. M., Nedosekov, V. V., & Hodovskyi, O. V. (2016). Pidbir ad’iuvantu dlia konstruiuvannia inaktyvovanoi vaktsyny proty infektsiinoho rynotrakheitu velykoi rohatoi khudoby [Selection of an adjuvant for the construction of the inactivated vaccine against infectious rhinotracheitis of cattle]. Veterynarna biotekhnolohiia. - Veterinary Biotechnology, 29, 93-99 [in Ukraine].

Hulyanych, M., Nedosekov, V., & Sobko, Y. (2016). Determination of Cultural Conditions of Infectious Bovine Rhinotracheitis Virus Strain “BM”. Annals of Agrarian Science, Elsevier, 14, 3, 201-204. Retrieved from http://www.sciencedirect.com/science/journal/15121887.


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