Вплив препарату «сіфузол» на рівень цитокінів у сироватці крові щурів за гострого запалення

Т. В. ЗВЕНІГОРОДСЬКА, Б. П. Киричко

Анотація


INFLUENCE OF PREPARATION "SIFUZOL" ON THE LEVEL OF SERUM CYTOKINES IN RATS WITH ACUTE INFLAMMATION

 

T. V. Zvenigorodska, B. P. Kirichko

 

Abstract. Search active compounds, without the side effects can influence the initial stages of initiation and development of inflammatory processes, it is the most important task of modern veterinary medicine. Our aim was to investigate the efficacy of a novel triazole "Sifuzol" in acute experimental inflammation in rats when administered subplantarno flogogennogo agent.

For the study were selected 60 mongrel male rats weighing 170-220 g and formed three groups: intact, control and experience. In the blood serum proinflammatory cytokines IL-1β, IL-6, TNF-α and anti-inflammatory cytokine IL-10 using test kits imunosorbentnogo enzyme analysis. It is found that the use of intramuscular sifuzola 6 mg for seven days to affect the cytokine profile of rats and promotes the healing process.

 Immunokorrektsionnoe drug effect is statistically significant decrease of proinflammatory cytokines IL-1β, IL-6, TNF-α in the serum of rats on the third day of the study (p <0.01) increase and anti-inflammatory cytokine IL-10 on the seventh day (p <0 05) compared to the control.


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