MORPHOLOGICAL CHANGES IN TISSUES OF THE KNEE JOINT OF THE RABBIT BECAUSE OF EXPERIMENTAL OSTEOARTHRITIS

Authors

  • Y. Demiantseva National University of Bioresources and Nature Management Of Ukraine
  • M. Maluyk Maluyk National University of Bioresources and Nature Management Of Ukraine
  • Y. Serdyukov National University of Bioresources and Nature Management Of Ukraine

Abstract

Osteoarthritis is the most common disease of the joints, in which
there is a disequilibrium between the processes of recovery and destruction in the
cartilage and bone located under the cartilage, as well as in surrounding tissues:
articular capsules, ligaments, muscles. For osteoarthritis, the structure of articular
cartilage changes due to the loss of proteoglycans, which leads to its destruction,
with atrophy of chondrocytes and the formation of new bone tissue around the
affected joint. That is why studying morphological changes in the tissues of the
knee joint allows us to confirm the presence of osteoarthritis. Studies have shown
that chronic retinol acetate can be used to simulate chronic sclerosing
osteoarthritis. Damage caused by retinol acetate can be identified as chronic
sclerosing osteoarthritis. In this case, there is a thinning of the hyaline cartilage or
its complete disappearance, the growth of dense fibrous connective tissue.
Histologic studies have shown that there are horizontal unbranched cracks
(fissures) in the cartilage tissue and in the fibrous connective tissue, the germs are
thinned or absent. The main signs of such a defect are almost fully expressed at 7
days after the injury and classified as a 5-degree defeat (according to the
classification of OARSI, 2000).
Keywords: knee joint, ostearthrosis modeling, rabbits, retinol
acetate, chronic sclerosing osteoarthritis

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Published

2019-03-05

Issue

No. 285 (2018)

Section

Article

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