Changes in immunological blood parameters whiz cryptosporidiosis of animals

Authors

  • Elena Zhurenko National University of Life and Environmental Sciences of Ukraine
  • Natalia Soroka National University of Life and Environmental Sciences of Ukraine
  • Vitaliy Zhurenko National University of Life and Environmental Sciences of Ukraine

DOI:

https://doi.org/10.31548/ujvs2019.01.051

Abstract

Thestudyofimmunologicalparametersis a keypointforthedetectionofimmunodeficiencyandimmunopathologicalconditions, theprimaryassessmentoftheimmunestatusofthebody, aswellasthediagnosis, treatmentandprognosisofthedisease. Thestateofhumoralimmunityforcryptosporidiosisisinsufficientlystudied, whichinhibitsthedecodingoftheroleofpathogeneticmechanismsinthedevelopmentofthedisease. Primaryinfectionwiththecausativeagentofcryptosporidiosiscausesananimalimmunobiologicalreorganizationinananimal'sorganism. Thedamagingfactorforcryptosporidiosisofcalvesisthepathogenitselfwithalldirectionsofitspathogenicaction. However, themechanismofactionandtheeffectsofthebiologicaleffectsofthepathogenand, firstofall, itsimmunobiologicalfactors, arenotsufficientlystudied.Thepurposeoftheworkwastostudytheimmunologicalparametersforcryptosporidiosis. Forresearch, cows, younganimalsofcattleandcalvesofblack-and-barkbreeds, spontaneouslyaffectedbythecausativeagentCryptosporidiumparvum, wereselectedforresearch. Bloodforresearchwastakenfromcalvesinthemorningbeforefeedingfromthejugularvein. Inconductingstudiesfor 35 daysinanimalsintheexperimentalgroupnotedanincreaseintheconcentrationofcirculatingimmunecomplexesby 10.5% relativetocontrol. Increasingtheconcentrationofcirculatingimmunecomplexesinserumofcalves, patientswithcryptosporidiosis, indicatesthepresenceofspecificinteractionantigen-antibodyanddecreasetheactivityofthehumorallinkoftheimmunesystem. Inthedeterminationofimmunosuppressiveproteins - serumcordsinserumofcalves, itwasfoundthatat 7, 14 daystheirconcentrationwaswithinthephysiologicallimits. Increasingtheconcentrationofcirculatingimmunecomplexesinserumofcalves, patientswithcryptosporidiosis, indicatesthepresenceofspecificinteractionantigen-antibodyanddecreasetheactivityofthehumorallinkoftheimmunesystem.

Keywords: cattle, immunesystem, cryptosporidiosis, circulatingimmunecomplexes, serumukoids, invasion

References

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Published

2019-04-26

Issue

Vol. 10 No. 1 (2019)

Section

Article

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