Effective use of hepatoprotector "Carsylin" in the event of occurrence of experimental chicken’s hepatitis

Abstract

Under the conditions of intensification of
manufacturing technologies in the field of commercial
poultry production, it is necessary to use the adaptive
and productive abilities of bird organism as high as
possible. In the majority of cases in the progress of
bacterial diseases of poultry stock, the development
of septic process is observed; this process is
characterized by infectious-toxic shock hepatic injury.
Poultry pseudomonosis is being an example of abovementioned
infections.
The purpose of research: development and
confirmation of hepatoprotective properties of a
comprehensive feed additive, produced on the basis of
silimarin, amino acids and vitamins for minimization
of pathogenic influence of bacterial and medical
stress factors for the purpose of its use in the poultry
farming.
The investigation of hepatoprotective properties of
a feed additive is carried out under the conditions of
infectious-toxic pseudomonous and medicamentous
Tetracyclinum hepatitis of broiler chicken ("Cobb-
500" crossing) aged under 14 days.
The assigned task of development of a comprehensive
feed additive with hepatoprotective properties for
the use in the field of poultry farming is executed by
way of superinducement of silimarin, betaine, ascorbic
acid (including vitamin Bm (carnitine HCl), choline
chloride, sorbitum, methionine and magnesium
sulfate) in the composition of solution.
As a result of application of feed additive "Carsylin"
in the event of experimental Tetracyclinum and
infectious-toxic pseudomonous hepatitis the
development of dystrophic, necrotizing, infiltration
conditions and hyperplastic infection in the structure
of liver are restricted. It is established that subsequent
to the results of rating semiquantitative estimation of
influence of feed additive "Carsylin" on the state of
liver of chickens under the conditions of infecting by P.
aeruginosa and administration of Tetracyclinum the
intensity of occurrence of the hepatocyte dystrophy,
necrotic changes, disorders of frame structure,
inflammatory infiltration was reduced by 41.7‑87.5%
in comparison with the indices of a group of control
pathology. Introduction of additive should be used for
prevention of development of cytolytic syndrome.