The sub-acute toxicity of the disinfectious preparation "Iodopovidone"
DOI:
https://doi.org/10.31548/poultry2023.01-02.008Keywords:
disinfectant, iodine polymer complex, subacute toxicity, laboratory ratsAbstract
The results of a preclinical study of the subacute toxicity of the disinfectant "Iodopovidone" are presented. The purpose of the experiment reflected in the article was to continue a series of preclinical studies of the disinfectant Iodopovidone on laboratory animals by examining subacute toxicity, to confirm good animal tolerance and the drug belongs to the 4th toxicity class – low-toxic substances. The experiment was carried out on laboratory white rats, which were kept in the vivarium of the Faculty of Veterinary Medicine of the National University of Life and Environmental Sciences of Ukraine in compliance with the requirements of the European Convention for the Protection of Vertebrate Animals used for scientific experiments or for other scientific purposes and the Law of Ukraine "On the Protection of Animals". The subacute toxicity of the disinfectant "Iodopovidone" was studied using dermal application. The effect of the drug was evaluated by analyzing the change in biochemical parameters of blood serum and hematological parameters of the blood of laboratory animals in dynamics after 6, 24 and 48 hours. The results of determining the parameters of subacute toxicity when applied to the skin indicate the absence of an irritating effect of the drug on the skin. Under the influence of the drug on the organism of animals for six hours, a slight fluctuation in hematological and biochemical blood parameters was revealed, which approached those of the control group of animals within 48 hours, except for the level of glucose, but this did not affect the general condition of the animals. The use of the drug at a dose of 2900 mg/kg of body weight does not cause the death of animals, which confirms the low toxicity of the drug and belonging to the 4th class of toxicity according to the current sanitary and hygienic standards, which is promising for use in poultry farming and requires further studies of chronic toxicity and toxicity in inhalation use.References
European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes. (1986). Strasbourg, 18.III.1986. URL: https://web.archive.org/web/20140115231036/http://conventions.coe.int/treaty/en/treaties/html/123.htm. [in English].
Gržinić, G., Piotrowicz-Cieślak, A., Klimkowicz-Pawlas, A., Górny, R. L., Ławniczek-Wałczyk, A., Piechowicz, L. ...& Wolska, L. (2023). Intensive
poultry farming: A review of the impact on the environment and human health. Science of The Total Environment, 858 (3). 160014. doi: 10.1016/j. scitotenv.2022.160014. [in English].
Kotsyumbas, I. Ya., Malyk, O. H., & Patereha, I. P. (2006). Doklinichni doslidzhennia veterynarnykh likarskykh zasobiv [Preclinical studies of veterinary medicinal products]. Lviv, 360. [in Ukrainian].
Luyckx, K., Van Coillie, E., Dewulf, J., Van Weyenberg, S., Herman, L., Zoons, J. …& De Reu, K. (2017). Identification and biocide susceptibility of dominant bacteria after cleaning and disinfection of broiler houses. Poultry Science, 96 (4), 938-949. doi: 10.3382/ps/pew355. [in English].
Rojs, O. Z., Zdovc, I., Dovč, A., Žgajnar, J., Slavec, B., Krapež, U., & Ambrožič, J. A. (2019). Presence and distribution of extended-spectrum and AmpC beta-lactamases-producing Escherichia coli on poultry farms in Slovenia. Journal of Applied Poultry Research, 28 (1), 200-209. doi: 10.3382/japr/pfy021. [in English].
Ricke S. C. (2021). Prebiotics and alternative poultry production. Poultry Science, 100 (7), 101174. doi: 10.1016/j.psj.2021.101174. [in English].
Zakon Ukrayiny. (2021). Pro zakhyst tvaryn vid zhorstokoho povodzhennia. 2006. № 3447-IV v redaktsii vid 08.08.2021 [About the protection of animals from cruelty. 2006. No. 3447-IV in the edition dated 08.08.2021]. Vidomosti Verkhovnoi Rady Ukrainy, 27б 230. Ofitsiinyi sait [Official website of the Verkhovna Rada of Ukraine]. Retrieved from https://zakon.rada.gov.ua/laws/show/3447-15#Text. [in Ukrainian].
Downloads
Published
Issue
Section
License
Relationship between right holders and users shall be governed by the terms of the license Creative Commons Attribution – non-commercial – Distribution On Same Conditions 4.0 international (CC BY-NC-SA 4.0):https://creativecommons.org/licenses/by-nc-sa/4.0/deed.uk
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
